Selma-Royo Marta, Dubois Léonard, Manara Serena, Armanini Federica, Cabrera-Rubio Raúl, Valles-Colomer Mireia, González Sonia, Parra-Llorca Anna, Escuriet Ramon, Bode Lars, Martínez-Costa Cecilia, Segata Nicola, Collado Maria Carmen
Institute of Agrochemistry and Food Technology-Spanish National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Cell Host Microbe. 2024 Jun 12;32(6):996-1010.e4. doi: 10.1016/j.chom.2024.05.005.
The composition and maturation of the early-life microbiota are modulated by a number of perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant microbiota transmission in two different birth environments: hospital-born (vaginal/cesarean) and home-born (vaginal) infants and their mothers. While delivery mode primarily explains initial compositional differences, place of birth impacts transmission timing-being early in homebirths and delayed in cesarean deliveries. Transmission patterns vary greatly across species and birth groups, yet certain species, like Bifidobacterium longum, are consistently vertically transmitted regardless of delivery setting. Strain-level analysis of B. longum highlights relevant and consistent subspecies replacement patterns mainly explained by breastfeeding practices, which drive changes in human milk oligosaccharide (HMO) degrading capabilities. Our findings highlight how delivery setting, breastfeeding duration, and other lifestyle preferences collectively shape vertical transmission, impacting infant gut colonization during early life.
生命早期微生物群的组成和成熟受到多种围产期因素的调节，这些因素在微生物垂直传播方面的相互作用仍未得到充分阐明。利用最新的菌株追踪方法，我们分析了两种不同出生环境下母亲向婴儿的微生物群传播情况：医院出生（阴道分娩/剖宫产）和家庭出生（阴道分娩）的婴儿及其母亲。虽然分娩方式主要解释了初始组成差异，但出生地点会影响传播时间——家庭分娩中传播较早，剖宫产中传播延迟。不同物种和出生组的传播模式差异很大，但某些物种，如长双歧杆菌，无论分娩方式如何，都能持续垂直传播。对长双歧杆菌的菌株水平分析突出了相关且一致的亚种替代模式，这主要由母乳喂养方式解释，母乳喂养方式会驱动人乳寡糖（HMO）降解能力的变化。我们的研究结果突出了分娩环境、母乳喂养持续时间和其他生活方式偏好如何共同塑造垂直传播，影响生命早期婴儿肠道的定植。
