Kim HanBi, Kwak InSuk, Kim MiSun, Um JiYoung, Lee SoYeon, Chung BoYoung, Park ChunWook, Won JongGu, Kim HyeOne
Department of Dermatology, College of Medicine, Hallym University, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Burn Center, Hallym University Hangang Sacred Heart Hospital, Seoul 07247, Republic of Korea.
Pharmaceutics. 2024 Sep 30;16(10):1283. doi: 10.3390/pharmaceutics16101283.
Patients with burn scars require effective treatments able to alleviate dry skin and persistent itching. Ion pairing has been employed in cosmetic formulations to enhance solubility in solvents and improve skin permeability. To evaluate the efficacy and safety of the cosmetic formula "RE:pair (arginine-glutamate ion pair)", we analyzed scar size, itching and pain, skin barrier function, scar scale evaluation, and satisfaction in our study participants. A total of 10 patients were recruited, and the formula was used twice a day for up to 4 weeks. Itching was significantly alleviated after 4 weeks of treatment (95% CI = -0.11-1.71) compared to before application (95% CI = 2.11-4.68). Transepidermal water loss (TEWL) showed an 11% improvement after 4 weeks (95% CI = 3.43-8.83) compared to before application (95% CI = 3.93-9.88), and skin coreneum hydration (SCH) showed a significant 41% improvement after 4 weeks (95% CI = 43.01-62.38) compared to before application (95% CI = 20.94-40.65). Based on the confirmation that RE:pair improves skin barrier function and relieves itching, it is likely to be used as a topical treatment for burn scars pending evaluation in follow-up studies (IRB no. HG2023-016).
烧伤疤痕患者需要有效的治疗方法来缓解皮肤干燥和持续瘙痒。离子对已被应用于化妆品配方中，以提高在溶剂中的溶解度并改善皮肤渗透性。为了评估化妆品配方“RE:pair（精氨酸 - 谷氨酸离子对）”的疗效和安全性，我们分析了研究参与者的疤痕大小、瘙痒和疼痛、皮肤屏障功能、疤痕量表评估以及满意度。总共招募了10名患者，该配方每天使用两次，最长使用4周。与使用前相比（95%置信区间 = 2.11 - 4.68），治疗4周后瘙痒明显减轻（95%置信区间 = -0.11 - 1.71）。与使用前相比（95%置信区间 = 3.93 - 9.88），4周后经表皮水分流失（TEWL）改善了11%（95%置信区间 = 3.43 - 8.83），并且4周后皮肤角质层水合作用（SCH）与使用前相比（95%置信区间 = 20.94 - 40.65）显著改善了41%（95%置信区间 = 43.01 - 62.38）。基于RE:pair改善皮肤屏障功能并缓解瘙痒的确认，在后续研究（机构审查委员会编号HG2023 - 016）评估之前，它很可能被用作烧伤疤痕的局部治疗方法。
