Cebrian Rosinéia Aparecida Vilela, Dalmagro Mariana, Pinc Mariana Moraes, Donadel Guilherme, Engel Larissa Aparecida, Bariccatti Reinaldo Aparecido, de Almeida Rafael Menck, de Aguiar Kelen Menezes Flores Rossi, Lourenço Emerson Luiz Botelho, Hoscheid Jaqueline
Laboratory of Preclinical Research of Natural Products, Paranaense University (UNIPAR), Umuarama 87502-210, Brazil.
Center for Engineering and Exact Sciences, State University of Western Paraná, Toledo 85903-220, Brazil.
Pharmaceutics. 2024 Oct 4;16(10):1294. doi: 10.3390/pharmaceutics16101294.
BACKGROUND/OBJECTIVES: Considering the antioxidant and antimicrobial properties attributed to compounds in extract, this research aimed to advance postoperative therapeutic innovations. Specifically, the study assessed the physicochemical properties of a film-forming solution (FFS) incorporated with , evaluating its therapeutic potential for postoperative applications.
The extract was meticulously characterized to determine its chemical composition, with particular emphasis on the concentration of phenolic compounds. Antioxidant and antimicrobial assays were conducted to assess the extract's efficacy in these domains. Following this, an FFS containing was formulated and evaluated comprehensively for skin adhesion, mechanical and barrier properties, and thermal behavior.
The antioxidant and antimicrobial activities of the extract demonstrated promising results, indicating its potential utility as an adjunct in postoperative care. The developed FFS exhibited favorable physicochemical properties for topical application, including adequate skin adhesion and appropriate pH levels. Moreover, chemical and thermal analyses confirmed the formulation's stability and the retention of the extract's beneficial properties.
Overall, the findings suggest that the -loaded FFS holds significant potential as a valuable therapeutic tool for post-surgical management.
背景/目的：鉴于提取物中的化合物具有抗氧化和抗菌特性，本研究旨在推进术后治疗创新。具体而言，该研究评估了含有[提取物名称]的成膜溶液（FFS）的物理化学性质，评估其在术后应用中的治疗潜力。
对[提取物名称]提取物进行了细致表征以确定其化学成分，特别关注酚类化合物的浓度。进行了抗氧化和抗菌试验以评估提取物在这些方面的功效。在此之后，配制了含有[提取物名称]的FFS，并对其皮肤粘附性、机械和屏障性能以及热行为进行了全面评估。
[提取物名称]提取物的抗氧化和抗菌活性显示出有前景的结果，表明其作为术后护理辅助剂的潜在用途。所开发的FFS表现出适合局部应用的良好物理化学性质，包括足够的皮肤粘附性和合适的pH值。此外，化学和热分析证实了制剂的稳定性以及提取物有益特性的保留。
总体而言，研究结果表明含[提取物名称]的FFS作为一种有价值的术后管理治疗工具具有巨大潜力。
