Fioccardi Annachiara, Donno Dario, Razafindrakoto Zoarilala Rinah, Tombozara Nantenaina, Henintsoa Sylvia, Mahitasoa Elyna, Torti Valeria, Solofoniaina Marcellin, Rosso Lorenzo, Gamba Giovanni, Andrianjara Charles, Ramanitrahasimbola David, Beccaro Gabriele Loris
Dipartimento di Scienze Agrarie, Forestali e Alimentari, Università degli Studi di Torino, 10095 Grugliasco, TO, Italy.
Institut Malgache de Recherches Appliquées, B.P. 3833, Antananarivo 101, Madagascar.
Plants (Basel). 2024 Oct 17;13(20):2899. doi: 10.3390/plants13202899.
(Myricaceae family) is a common plant from Madagascar and is present on the IUCN Red List of threatened species classified at the 'least concern' level, used by the local population to treat numerous illnesses and pain. Despite its frequent use, comprehensive phytochemical and pharmacological research on the species is limited. This study evaluated the antioxidant, analgesic, and anti-inflammatory properties, as well as the toxicity of methanol extracts from the leaves (MS_L) and bark (MS_B) of . The research involved the analysis of nutritional traits such as sugars, organic acids, vitamin C, polyphenolic content (TPC) and the main phytochemicals by HPLC analysis. Antioxidant capacity was assessed through DPPH and FRAP assays. Analgesic and anti-inflammatory activities were evaluated using acetic acid-induced writhing and carrageenan-induced paw oedema tests in mice. The results showed a high content of phenolic and bioactive components in the leaf and bark extracts, associated with antioxidant, analgesic and anti-inflammatory properties. The interaction of key compounds such as ferulic acid and ellagic acid with proteins involved in pH regulation and immune modulation provides clues to the mechanisms underlying the therapeutic effects. However, conservation efforts are crucial due to habitat loss and illegal logging, and further studies are needed to fully explore the plant's therapeutic potential.
（杨梅科）是一种原产于马达加斯加的常见植物，在世界自然保护联盟濒危物种红色名录中被列为“无危”级别，当地居民用它来治疗多种疾病和疼痛。尽管其使用频繁，但对该物种的全面植物化学和药理学研究仍然有限。本研究评估了[植物名称]叶片（MS_L）和树皮（MS_B）甲醇提取物的抗氧化、镇痛和抗炎特性以及毒性。研究包括通过高效液相色谱分析对糖、有机酸、维生素C、多酚含量（TPC）等营养特性以及主要植物化学物质进行分析。通过DPPH和FRAP试验评估抗氧化能力。使用乙酸诱导的扭体试验和角叉菜胶诱导的小鼠足爪肿胀试验评估镇痛和抗炎活性。结果表明，叶片和树皮提取物中酚类和生物活性成分含量较高，具有抗氧化、镇痛和抗炎特性。阿魏酸和鞣花酸等关键化合物与参与pH调节和免疫调节的蛋白质之间的相互作用为治疗作用的潜在机制提供了线索。然而，由于栖息地丧失和非法采伐，保护工作至关重要，需要进一步研究以充分探索该植物的治疗潜力。
