Serquiz Alexandre Coelho, Barros Gomes Joana de Angelis da Costa, Farias Naisandra Bezerra da Silva, Mafra Denise, Pereira de Lima Pietra Maria, de Oliveira Coutinho Daniella, Ribeiro Fernanda Priscila Barbosa, Rocha Hugo Alexandre de Oliveira, de Brito Alves José Luiz
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.
Laboratory of Biotechnology of Natural Polymers (BIOPOL), Graduate Program of Biochemistry and Molecular Biology, Bioscience Center, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, RN, Brazil.
Pharmaceuticals (Basel). 2024 Oct 18;17(10):1393. doi: 10.3390/ph17101393.
Cadmium (Cd), a highly toxic heavy metal from agricultural activities, and its exposure can lead to impaired renal function by increasing reactive oxygen species. The atemoya fruit is known for its high phenolic and antioxidant compounds. This study aimed to evaluate the effects of atemoya extracts on renal function, oxidative stress parameters, and inflammatory biomarkers in a cadmium-induced nephrotoxicity model.
Three aqueous extracts were prepared from different parts of the atemoya fruit: seeds, peel, and pulp. Twenty-five male rats were allocated into four groups: control, seed, peel, and pulp extracts at 2 g/kg for 25 days. All treatment groups administered intraperitoneal injections of cadmium chloride (CdCl) (2 mg/kg) to induce renal damage.
The cadmium-treated groups showed decreased creatinine clearance, SOD, CAT, and GPx activities ( < 0.05) and increased serum levels of TNF-α and IL-6 compared to the control group ( < 0.05). The treatment with seed, peel, and pulp extracts increased creatinine clearance ( < 0.05), increased SOD, CAT, and GPx activities ( < 0.05), and reduced serum levels of TNF-α and IL-6 compared to the Cd group ( < 0.05).
This study supports the use of atemoya as a promising candidate for mitigating nephrotoxicity and highlights the importance of its antioxidant and anti-inflammatory properties in renal health.
镉（Cd）是一种来自农业活动的剧毒重金属，接触镉会通过增加活性氧导致肾功能受损。凤梨释迦果实以其高含量的酚类和抗氧化化合物而闻名。本研究旨在评估凤梨释迦提取物对镉诱导的肾毒性模型中肾功能、氧化应激参数和炎症生物标志物的影响。
从凤梨释迦果实的不同部位制备了三种水提取物：种子、果皮和果肉。将25只雄性大鼠分为四组：对照组、种子提取物组、果皮提取物组和果肉提取物组，各提取物组按2 g/kg给药，持续25天。所有处理组均腹腔注射氯化镉（CdCl）（2 mg/kg）以诱导肾损伤。
与对照组相比，镉处理组的肌酐清除率、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）活性降低（P<0.05），血清肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平升高（P<0.05）。与镉处理组相比，种子、果皮和果肉提取物处理可提高肌酐清除率（P<0.05），增加SOD、CAT和GPx活性（P<0.05），并降低血清TNF-α和IL-6水平（P<0.05）。
本研究支持将凤梨释迦作为减轻肾毒性的有前景的候选物，并强调了其抗氧化和抗炎特性在肾脏健康中的重要性。
