Department of Nutrition, Health Sciences Center, Federal University of Paraiba, Joao Pessoa, Paraíba, Brazil.
Departament of Biochemistry, Biological Sciences Center, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Probiotics Antimicrob Proteins. 2023 Jun;15(3):601-613. doi: 10.1007/s12602-021-09878-1. Epub 2021 Nov 24.
This study assessed the effects of a mixed formulation containing Limosilactobacillus (L.) fermentum 139, L. fermentum 263, and L. fermentum 296 on cardiometabolic parameters, inflammatory markers, short-chain fatty acid (SCFA) fecal contents, and oxidative stress in colon, liver, heart, and kidney tissues of female rats fed a high-fat diet (HFD). Female Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6). L. fermentum formulation (1 × 10 CFU/mL of each strain) was administered two twice a day for 4 weeks. Administration of L. fermentum increased acetate and succinate fecal contents and reduced hyperlipidemia and hyperglycemia in rats fed a HFD (p < 0.05). Administration of L. fermentum decreased low-grade inflammation and improved antioxidant capacity along the gut, liver, heart, and kidney tissues in female rats fed a HFD (p < 0.05). Administration of L. fermentum prevented dyslipidemia, inflammation, and oxidative stress in colon, liver, heart, and kidney in female rats fed a HFD.
本研究评估了含有 Limosilactobacillus（L.）fermentum 139、L. fermentum 263 和 L. fermentum 296 的混合配方对高脂肪饮食（HFD）喂养的雌性大鼠的心脏代谢参数、炎症标志物、短链脂肪酸（SCFA）粪便含量以及结肠、肝脏、心脏和肾脏组织的氧化应激的影响。将雌性 Wistar 大鼠分为对照饮食（CTL，n=6）、HFD（n=6）和 HFD 接受 L. fermentum 配方（HFD-LF，n=6）。L. fermentum 配方（每种菌株 1×10 CFU/mL）每天两次给药，持续 4 周。L. fermentum 的给药增加了粪便中的乙酸盐和琥珀酸盐含量，并降低了 HFD 喂养大鼠的高脂血症和高血糖（p<0.05）。L. fermentum 的给药降低了 HFD 喂养雌性大鼠的低水平炎症，并改善了肠道、肝脏、心脏和肾脏组织中的抗氧化能力（p<0.05）。L. fermentum 的给药预防了 HFD 喂养的雌性大鼠的结肠、肝脏、心脏和肾脏中的血脂异常、炎症和氧化应激。
