Key Laboratory for Quality Evaluation of Bulk Herbs of Human Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Molecules. 2024 Oct 10;29(20):4790. doi: 10.3390/molecules29204790.
Glucose and lipid metabolism disorders are the core pathological mechanism of a variety of metabolic diseases, and the incidence of related diseases is increasing year by year, which seriously threatens human life and health. Traditional Chinese medicine with medicinal and edible properties refers to Chinese medicinal resources that have both medicinal and edible characteristics. Due to its safety and its health-promoting and medicinal functions, traditional Chinese medicine has received increasing attention in the development of functional health foods. Phenolic acids are important secondary metabolites that are ubiquitous in medicinal and edible homologous plants, and the regulation of glycolipid metabolism is an important activity and plays a key role in many diseases. In this paper, we focus on the alleviation of glycolipid disorders using MEHH phenolic acids, which regulate glucose metabolism and lipid metabolism, improve insulin resistance, inhibit inflammatory responses, alleviate oxidative stress, and regulate intestinal flora; additionally, we summarize the mechanism in order to provide a reference for MEHH phenolic acids in the treatment of glycolipid metabolism diseases.
糖脂代谢紊乱是多种代谢性疾病的核心病理机制,相关疾病的发病率逐年上升,严重威胁人类生命健康。药食同源中药是指兼具药用和食用特性的中药材资源。由于其安全性以及具有的促进健康和药用功能,药食同源中药在功能性保健食品的开发中受到越来越多的关注。酚酸类化合物是药用和食用同源植物中普遍存在的重要次生代谢产物,调节糖脂代谢是其重要活性之一,在多种疾病中发挥关键作用。本文主要关注 MEHH 酚酸类化合物通过调节葡萄糖代谢和脂代谢、改善胰岛素抵抗、抑制炎症反应、缓解氧化应激、调节肠道菌群来缓解糖脂代谢紊乱,同时对其作用机制进行综述,以期为 MEHH 酚酸类化合物治疗糖脂代谢疾病提供参考。