HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia.
Department of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA.
Int J Mol Sci. 2023 Apr 26;24(9):7898. doi: 10.3390/ijms24097898.
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.
代谢综合征是一组与 2 型糖尿病和心血管疾病（CVDs）风险相关的病症。代谢综合征与肥胖密切相关。脂肪增加会促进炎症和氧化应激，这是涉及代谢综合征成分的各种并发症的前兆，即胰岛素抵抗、高血压和高脂血症。越来越多的研究证实了氧化应激和慢性炎症在代谢综合征发病机制中的重要性。然而，很少有研究综述了氧化应激在导致代谢综合征中的作用机制。在这篇综述中，我们强调了活性氧（ROS）增加线粒体功能障碍、蛋白质损伤、脂质过氧化以及损害代谢综合征中抗氧化功能的机制。氧化应激的生物标志物可用于疾病诊断和严重程度评估。
