Department of Rheumatology, Clinic of Rheumatology, University Hospital St. Ivan Rilski, Urvich Str. 13, 1612 Sofia, Bulgaria.
Faculty of Medicine, Medical University of Sofia, Urvich Str. 13, 1612 Sofia, Bulgaria.
Medicina (Kaunas). 2024 Sep 25;60(10):1574. doi: 10.3390/medicina60101574.
Coronary artery disease (CAD) presents a significant risk for patients with systemic vasculitides, a group of disorders characterized by the inflammation of blood vessels. In this review, we focus on the pathophysiological mechanisms, complications, and management strategies for CAD in systemic vasculitides. We highlight how the inflammatory processes inherent in vasculitis contribute to accelerated atherosclerosis and myocardial ischemia. Key strategies in managing CAD in this patient population include using medicine treatments to mitigate vascular inflammation while balancing the risk of promoting cardiovascular events and lifestyle modifications. Understanding the nuanced relationship between systemic vasculitides and CAD is crucial for improving patient outcomes and guiding therapeutic approaches.
冠状动脉疾病 (CAD) 对系统性血管炎患者构成重大风险，后者是一组以血管炎症为特征的疾病。在本次综述中，我们专注于系统性血管炎患者 CAD 的病理生理学机制、并发症和管理策略。我们强调了血管炎固有炎症过程如何导致动脉粥样硬化加速和心肌缺血。管理该患者群体 CAD 的关键策略包括使用药物治疗减轻血管炎症，同时平衡促进心血管事件的风险和生活方式的改变。理解系统性血管炎和 CAD 之间的细微关系对于改善患者预后和指导治疗方法至关重要。
