Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia.
Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia.
Medicina (Kaunas). 2024 Sep 28;60(10):1594. doi: 10.3390/medicina60101594.
Atrial fibrillation (AF) significantly impacts the quality of life (QoL) of affected individuals. Pulmonary vein isolation (PVI) has emerged as a therapeutic approach to manage AF and improve QoL. This study aimed to assess the QoL in patients with AF undergoing PVI. A total of 97 AF patients undergoing PVI (radiofrequency 52.6% (n = 51) and cryoablation 47.4% (n = 46)) at Pauls Stradins Clinical University Hospital were included in this study. QoL was measured using the 36-Item Short-Form Survey (SF-36) before PVI and during a follow-up period of 5.98 ± 1.97 months. This study consisted of 60.8% (n = 59) males, with a mean age of 60.06 ± 11.61 years. A total of 67.0% (n = 65) of patients had paroxysmal AF, and 33.0% (n = 32) had persistent AF. The SF-36 questionnaire revealed major improvements across multiple QoL domains post-PVI, reaching a statistical significance of < 0.01. Patient factors, such as female gender ([estimate 21.26, 95% CI (7.18, 35.35)], < 0.01), persistent AF ([estimate 15.49, 95% CI (2.83, 28.15)], = 0.02), and restored sinus rhythm ([estimate 14.35, 95% CI (1.65, 27.06)], = 0.03), were associated with significantly improved QoL. PVI in patients with AF positively influences various dimensions of QoL, as evidenced by significant improvement across multiple SF-36 domains. These findings emphasize worsened QoL in patients with AF and the potential benefits of PVI enhancing the overall wellbeing of individuals with AF.
心房颤动（AF）显著影响受影响个体的生活质量（QoL）。肺静脉隔离（PVI）已成为管理 AF 和改善 QoL 的治疗方法。本研究旨在评估接受 PVI 的 AF 患者的 QoL。本研究共纳入了 97 例在 Pauls Stradins 临床大学医院接受 PVI（射频消融 52.6%（n=51）和冷冻消融 47.4%（n=46））的 AF 患者。在 PVI 前和随访期间 5.98±1.97 个月，使用 36 项简短健康调查问卷（SF-36）测量 QoL。本研究包括 60.8%（n=59）的男性，平均年龄为 60.06±11.61 岁。共有 67.0%（n=65）的患者患有阵发性 AF，33.0%（n=32）的患者患有持续性 AF。SF-36 问卷显示，PVI 后多个 QoL 领域有显著改善，达到统计学意义（P<0.01）。患者因素，如女性性别（[估计值 21.26，95%置信区间（7.18，35.35）]，P<0.01）、持续性 AF（[估计值 15.49，95%置信区间（2.83，28.15）]，P=0.02）和窦性节律恢复（[估计值 14.35，95%置信区间（1.65，27.06）]，P=0.03）与 QoL 的显著改善相关。AF 患者的 PVI 对 QoL 的多个维度产生积极影响，这体现在多个 SF-36 领域的显著改善。这些发现强调了 AF 患者 QoL 的恶化以及 PVI 增强 AF 患者整体健康的潜在益处。
