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甲状腺毒症性周期性瘫痪:一位看似健康的年轻患者四肢瘫痪的罕见病因。

Thyrotoxic Periodic Paralysis: A Rare Cause of Quadriparesis in a Young and Seemingly Healthy Patient.

机构信息

Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania.

Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.

出版信息

Medicina (Kaunas). 2024 Oct 14;60(10):1685. doi: 10.3390/medicina60101685.

Abstract

Hypokalemia is a common laboratory finding in hospitalized patients, typically resulting from insufficient potassium intake, renal or gastrointestinal losses, or intracellular shifts. While the underlying cause is often easily identifiable, certain cases present diagnostic challenges, and if left unrecognized, the consequences can be life-threatening. We report a rare and atypical case of severe symptomatic hypokalemia as the initial presentation of newly diagnosed Graves' disease. The condition was caused by thyrotoxic periodic paralysis, a rare but serious complication of thyrotoxicosis, predominantly seen in East Asian populations. This disorder is characterized by episodes of acute, reversible muscle weakness associated with transient hypokalemia, which increases the risk of falls and traumatic injuries. The prompt identification of the etiology in such cases is critical for preventing recurrence and avoiding potentially fatal complications.

摘要

低血钾症是住院患者中常见的实验室发现,通常是由于钾摄入不足、肾或胃肠道丢失,或细胞内转移所致。虽然潜在的原因通常很容易识别,但某些情况下会出现诊断挑战,如果未被识别,后果可能危及生命。我们报告了一例罕见且非典型的严重症状性低血钾症作为新诊断的 Graves 病的初始表现。这种情况是由甲状腺毒性周期性瘫痪引起的,这是甲状腺毒症的一种罕见但严重的并发症,主要见于东亚人群。这种疾病的特征是急性、可逆性肌无力伴有短暂性低钾血症,增加跌倒和创伤性损伤的风险。在这种情况下,及时确定病因对于预防复发和避免潜在致命并发症至关重要。

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