Department of Pharmacology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Department of General Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Medicina (Kaunas). 2024 Oct 17;60(10):1705. doi: 10.3390/medicina60101705.
: The complexity of antiretroviral therapy (ART) regimens in people living with HIV (PLHIV) poses significant challenges for medication management, impacting adherence and overall health outcomes. The Medication Regimen Complexity Index (MRCI) is a tool that quantifies regimen complexity, yet its correlation with hospitalization rates and adverse drug reactions (ADRs) in PLHIV remains underexplored. : This prospective study, which was conducted at a government-funded antiretroviral treatment center, investigated the relationships among MRCI scores, hospitalization due to ADRs, and the ADR rates in 285 PLHIV participants over 18 months. : The study revealed a significant association between higher baseline MRCI scores and hospitalization due to ADRs, with a threshold MRCI score of 8 indicating increased risk. There was no significant association between average MRCI scores and overall ADR rates or non-ADR-related hospitalizations. : These findings emphasize the importance of monitoring medication regimen complexity in PLHIV, particularly in the context of preventing hospitalizations related to ADRs. Further research is needed to understand the multifactorial influences on ADR occurrence and to optimize ART regimens for better patient outcomes.
：抗逆转录病毒疗法（ART）方案的复杂性给艾滋病毒感染者（PLHIV）的药物管理带来了重大挑战，影响了他们的依从性和整体健康结果。药物治疗方案复杂性指数（MRCI）是一种量化方案复杂性的工具，但它与 PLHIV 的住院率和药物不良反应（ADR）之间的相关性仍未得到充分探索。：这项前瞻性研究在一家政府资助的抗逆转录病毒治疗中心进行，调查了 285 名 18 个月内的 PLHIV 参与者的 MRCI 评分、因 ADR 导致的住院治疗和 ADR 发生率之间的关系。：研究表明，较高的基线 MRCI 评分与因 ADR 导致的住院治疗之间存在显著关联，MRCI 评分阈值为 8 表明风险增加。平均 MRCI 评分与整体 ADR 发生率或与非 ADR 相关的住院治疗之间没有显著关联。：这些发现强调了监测 PLHIV 药物治疗方案复杂性的重要性，特别是在预防与 ADR 相关的住院治疗方面。需要进一步研究来了解影响 ADR 发生的多因素，并优化 ART 方案以改善患者的治疗效果。
