Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China.
Virulence. 2024 Dec;15(1):2421231. doi: 10.1080/21505594.2024.2421231. Epub 2024 Nov 20.
Hepatitis B virus (HBV) infection poses a challenge to global public health. Persistent liver infection with HBV is associated with an increased risk of developing severe liver disease. The complex interaction between the virus and the host is the reason for the persistent presence of HBV and the risk of tumor development. Chronic liver inflammation, integration of viral genome with host genome, expression of HBx protein, and viral genotype are all key participants in the pathogenesis of hepatocellular carcinoma (HCC). Epigenetic regulation in HBV-associated HCC involves complex interactions of molecular mechanisms that control gene expression and function without altering the underlying DNA sequence. These epigenetic modifications can significantly affect the onset and progression of HCC. This review summarizes recent research on the epigenetic regulation of HBV persistent infection and HBV-HCC development, including DNA methylation, histone modification, RNA modification, non-coding RNA, etc. Enhanced knowledge of these mechanisms will offer fresh perspectives and potential targets for intervention tactics in HBV-HCC.
乙型肝炎病毒 (HBV) 感染对全球公共卫生构成挑战。HBV 的持续肝脏感染与发生严重肝脏疾病的风险增加相关。病毒和宿主之间的复杂相互作用是 HBV 持续存在和肿瘤发展风险的原因。慢性肝脏炎症、病毒基因组与宿主基因组的整合、HBx 蛋白的表达以及病毒基因型都是肝细胞癌 (HCC) 发病机制中的关键参与者。HBV 相关 HCC 的表观遗传调控涉及控制基因表达和功能的分子机制的复杂相互作用，而不会改变潜在的 DNA 序列。这些表观遗传修饰可以显著影响 HCC 的发生和进展。本综述总结了 HBV 持续感染和 HBV-HCC 发展的表观遗传调控的最新研究，包括 DNA 甲基化、组蛋白修饰、RNA 修饰、非编码 RNA 等。对这些机制的深入了解将为 HBV-HCC 的干预策略提供新的视角和潜在靶点。
