Muğla Sıtkı Koçman University, Faculty of Dentistry, Department of Periodontology, Muğla 48000, Turkey.
Muğla Sıtkı Koçman University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Muğla 48000, Turkey.
Arch Oral Biol. 2025 Jan;169:106116. doi: 10.1016/j.archoralbio.2024.106116. Epub 2024 Oct 20.
The aim of this study was to evaluate salivary matrix metalloproteinase-9 (MMP-9) and melatonin levels in individuals with periodontal health, gingivitis, and periodontitis.
A total of 170 participants were enrolled in this study. They included 57 periodontally healthy individuals, 58 gingivitis patients, and 55 periodontitis patients. Saliva samples were collected by passive drool technique. The levels of MMP-9 and melatonin in saliva were measured biochemically using the ELISA method.
Salivary MMP-9 levels in the periodontitis group were significantly higher than those in the gingivitis and periodontally healthy groups, while salivary melatonin levels were significantly lower (p<0.001). A positive correlation was observed between clinical periodontal parameters and salivary MMP-9 levels, while salivary melatonin levels were negatively correlated (p<0.001). A negative correlation was also observed between salivary MMP-9 levels and salivary melatonin levels (p<0.001).
This study shows that the level of melatonin in saliva is associated with periodontal disease and with the level of MMP-9 in saliva, which plays a role in this disease.
本研究旨在评估牙周健康、牙龈炎和牙周炎患者唾液中基质金属蛋白酶-9（MMP-9）和褪黑素的水平。
本研究共纳入 170 名参与者，包括 57 名牙周健康者、58 名牙龈炎患者和 55 名牙周炎患者。采用被动流涎技术收集唾液样本。采用 ELISA 法检测唾液中 MMP-9 和褪黑素的水平。
牙周炎组唾液 MMP-9 水平明显高于牙龈炎组和牙周健康组，而唾液褪黑素水平明显降低（p<0.001）。临床牙周参数与唾液 MMP-9 水平呈正相关，而与唾液褪黑素水平呈负相关（p<0.001）。唾液 MMP-9 水平与唾液褪黑素水平呈负相关（p<0.001）。
本研究表明，唾液中褪黑素的水平与牙周病以及唾液中 MMP-9 的水平有关，MMP-9 水平在牙周病中发挥作用。
