Department of Public Health and Healthcare Management, Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan.
Department of Public Health and Healthcare Management, Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan
BMJ Open Respir Res. 2024 Oct 26;11(1):e002554. doi: 10.1136/bmjresp-2024-002554.
Uzbekistan is one of the 30 countries with the highest tuberculosis (TB) morbidity, accounting for 87% of all cases globally. The incidence of TB in the Republic of Karakalpakstan (RK) remains consistently high in comparison with other regions of Uzbekistan. The incidence rates of TB strongly differ even among the regions within RK. In 2019, the highest rates were registered in the northern and north-western regions, and the lowest in the southern regions. An important issue is the extent to which specific residencies impact individual health. The ethnic composition of the population of RK can be one of the possible causes for such geographical heterogeneity in TB morbidity.
The case-control design of this study primarily aims to evaluate the role of ethnicity and residency on the development of active TB in the community living in RK. Additionally, the study aims to measure the association between factors of TB morbidity and ethnicity/residency in the community of RK. It was decided to include one matched control for every included case, to control potential confounders. Cases with clinically diagnosed or bacteriologically confirmed TB will be randomly sampled from the patient registry. Controls will comprise individuals without TB, living in RK at the same time as the cases. They will be randomly sampled from a general roster of the residents.
This study was approved by the Bioethics Committee of the Medical Association of Uzbekistan (approval report of meeting #1 on 18 January 2024). The results of this study will be widely disseminated at scientific meetings and conferences, and published in a peer-reviewed journal.
乌兹别克斯坦是结核病（TB）发病率最高的 30 个国家之一，占全球所有病例的 87%。与乌兹别克斯坦其他地区相比，卡拉卡尔帕克斯坦共和国（RK）的结核病发病率一直居高不下。RK 内部各地区的结核病发病率差异很大。2019 年，发病率最高的是北部和西北部地区，南部地区最低。一个重要的问题是，特定的居住地对个人健康的影响程度。RK 的人口民族构成可能是结核病发病率存在地域差异的原因之一。
本研究采用病例对照设计，主要目的是评估民族和居住地对 RK 社区人群中活动性结核病发展的影响。此外，该研究旨在衡量 RK 社区中结核病发病率的民族/居住地因素之间的关联。决定每例纳入病例匹配一名对照，以控制潜在的混杂因素。将从患者登记处随机抽取临床诊断或细菌学确诊的结核病病例。对照组将包括在同一时间居住在 RK 且无结核病的个体。他们将从居民的一般名单中随机抽取。
这项研究得到了乌兹别克斯坦医学协会生物伦理委员会的批准（2024 年 1 月 18 日第 1 次会议的批准报告）。这项研究的结果将在科学会议和会议上广泛传播，并发表在同行评议的期刊上。
