Department of Emergency Medicine, Shenzhen Luohu Hospital Group Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Department of Cardiology, Shenzhen Luohu Hospital Group Luohu People's, Hospital The Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
BMC Cardiovasc Disord. 2024 Oct 26;24(1):595. doi: 10.1186/s12872-024-04281-4.
The inflammatory burden index (IBI), a novel inflammation-based indicator, to is associated with the presence and prognosis of various diseases. However, few studies have focused on exploring the relationship between IBI and the coronary slow flow phenomenon (CSFP). In this study, we aimed to investigate the predictive value of IBI for CSFP in patients with chest pain and no obstructive coronary artery disease.
A total of 1126 individuals with chest pain and no obstructive coronary arteries were consecutively included in this study. 71 patients developed CSFP were included in the CSFP group. A 1:2 age- and sex-matched patient with normal blood flow and angiographically proven normal coronary arteries was selected as the control group (n = 142). Plasma C-reactive protein (CRP), neutrophil, and lymphocyte counts were measured to determine the value of IBI.
The IBI were significantly higher in the CSFP group than in the controls (21.1 ± 6.5 vs. 14.5 ± 6.4, P < 0.001). The IBI increasedelevated with the increase of the numbers of vessels affected by CSFP. Multivariate logistic regression analysis revealed that IBI and body mass index (BMI) were independent predictors of CSFP. Receiver operating characteristic (ROC) curve analysis showed that when IBI was > 15.74, the sensitivity and specificity were 77.5% and 67.6%, respectively, and the area under the ROC curve (AUC) was 0.799 (95% CI: 0.737-0.862, P<0.001).
The IBI may be an independent predictor of CSFP in patients with chest pain and normal coronary arteries. The IBI could improve the predictive value of CSFP compared with the indicators alone.
炎症负担指数（IBI）是一种新的基于炎症的指标，与各种疾病的存在和预后相关。然而，很少有研究关注 IBI 与冠状动脉慢血流现象（CSFP）之间的关系。本研究旨在探讨 IBI 对胸痛且无阻塞性冠状动脉疾病患者 CSFP 的预测价值。
本研究连续纳入 1126 例胸痛且无阻塞性冠状动脉的患者。其中 71 例发生 CSFP 的患者纳入 CSFP 组，选择年龄和性别匹配的 1:2 例血流正常且经血管造影证实正常的冠状动脉患者作为对照组（n=142）。测定血浆 C 反应蛋白（CRP）、中性粒细胞和淋巴细胞计数，以确定 IBI 的价值。
CSFP 组的 IBI 明显高于对照组（21.1±6.5 比 14.5±6.4，P<0.001）。随着 CSFP 受累血管数量的增加，IBI 升高。多变量 logistic 回归分析显示，IBI 和体重指数（BMI）是 CSFP 的独立预测因子。受试者工作特征（ROC）曲线分析显示，当 IBI>15.74 时，敏感性和特异性分别为 77.5%和 67.6%，ROC 曲线下面积（AUC）为 0.799（95%CI：0.737-0.862，P<0.001）。
IBI 可能是胸痛且无阻塞性冠状动脉疾病患者 CSFP 的独立预测因子。与单独的指标相比，IBI 可以提高 CSFP 的预测价值。
