Department of Pediatric Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Department of Encephalopathy, Baise Traditional Chinese Medicine Hospital, Baise, China.
Nutr Metab Cardiovasc Dis. 2024 Jan;34(1):64-74. doi: 10.1016/j.numecd.2023.10.006. Epub 2023 Oct 10.
The objective of this study was to investigate the association between inflammatory burden index (IBI) and all-cause mortality in the general population aged over 45 years.
The study included 8827 participants from the National Health and Examination Nutrition Survey (NHANES) who were aged over 45 years. The IBI was calculated using three markers: C-reaction protein × neutrophil/lymphocyte, and all the participants were classified into four groups (Quartile 1: IBI ≤0.178, N = 2206; Quartile 2: 0.178 <IBI ≤0.440, N = 2219; Quartile 3: 0.440 <IBI ≤1.099, N = 2195; Quartile 4: IBI >1.099, 2207). Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95 % confidence interval (CI) for the association between IBI and all-cause mortality. During a median follow-up of 129 month, 2431 deaths occurred. The all-cause mortality rate in Quartile 1, Quartile 2, Quartile 3 and Quartile 4 was 14.76 %, 17.67 %, 23.18 % and 29.69 %, respectively (p < 0.001). After adjustment for demographic, and potential clinical factors, higher IBI was significantly associated with an increased risk of all-cause mortality (Quartile 3 vs. Quartile 1: HR = 1.26, 95 % CI: 1.08 to 1.46, p = 0.003; Quartile 4 vs. Quartile 1: HR = 1.59, 95 % CI: 1.40 to 1.80, p < 0.001). Furthermore, the results of the restricted cubic spline analysis suggested that the association between IBI and all-cause mortality was nonlinear and positive, without specific threshold value.
This study supports that higher IBI is associated with an increased risk of all-cause mortality in the general population aged over 45 years.
本研究旨在探讨炎症负担指数（IBI）与 45 岁以上人群全因死亡率之间的关系。
本研究纳入了来自国家健康与营养检查调查（NHANES）的 8827 名 45 岁以上的参与者。使用三种标志物计算 IBI：C 反应蛋白×中性粒细胞/淋巴细胞，将所有参与者分为四组（第 1 四分位数：IBI≤0.178，N=2206；第 2 四分位数：0.178<IBI≤0.440，N=2219；第 3 四分位数：0.440<IBI≤1.099，N=2195；第 4 四分位数：IBI>1.099，N=2207）。使用 Cox 比例风险回归模型估计 IBI 与全因死亡率之间的关联的风险比（HR）和 95%置信区间（CI）。在中位数为 129 个月的随访期间，发生了 2431 例死亡。第 1、2、3 和 4 四分位数的全因死亡率分别为 14.76%、17.67%、23.18%和 29.69%（p<0.001）。在调整人口统计学和潜在临床因素后，较高的 IBI 与全因死亡率增加显著相关（第 3 四分位数与第 1 四分位数：HR=1.26，95%CI：1.08 至 1.46，p=0.003；第 4 四分位数与第 1 四分位数：HR=1.59，95%CI：1.40 至 1.80，p<0.001）。此外，限制三次样条分析的结果表明，IBI 与全因死亡率之间的关系是非线性和阳性的，没有特定的阈值。
本研究支持在 45 岁以上人群中，较高的 IBI 与全因死亡率增加相关。
