健康饮品指数（HBI）与乳腺癌（BrCa）风险的相关性：一项病例对照研究。
Associations of the Healthy Beverage Index (HBI) and the risk of Breast Cancer (BrCa): a case-control study.
机构信息
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
BMC Womens Health. 2024 Oct 26;24(1):573. doi: 10.1186/s12905-024-03411-6.
BACKGROUND
Breast cancer (BrCa) is one of the leading causes of cancer-related deaths. There are several factors for getting BrCa, including some changeable factors related to lifestyle like unhealthy dietary patterns, so modifying them can prevent one third of the complications and deaths caused by BrCa. Therefore, we decided to investigate the relationship between Healthy Beverage Index (HBI) and the risk of BrCa.
METHODS
In this hospital-based case-control study, 253 patients with BrCa and 267 non-BrCa controls were enrolled. Food consumption was recorded to calculate the HBI score using a semi-quantitative Food Frequency Questionnaire (FFQ). Additionally, by using binary logistic regression analysis with adjustment for confounders, the relationship between HBI and the risk of BrCa were assessed. HBI was established by Duffey et al. and is used to evaluate the overall quality of beverage intake and identify changes in consumption.
RESULTS
Mean ± SD of age and BMI of the study participants were 47.92 ± 10.33 years and 29.43 ± 5.51 kg/m, respectively. Patients with BrCa considerably outperformed controls in terms of waist circumference (WC), age at first pregnancy, history of abortion, and number of children(Pvalue < 0.05). Compared with those in the lowest quartile of HBI, subjects in the highest quartile had higher intake of energy, carbohydrate, protein, fat, fiber, sodium, potassium, calcium, magnesium, zinc, vitamin C, E, B9, fruits, vegetables, fish and nut as well as lower BMI and WC (Pvalue < 0.05). After adjustment for potential confounders, individuals in highest compared to lowest quartile of HBI had significantly lower risk of BrCa for total population (odds ratio (OR): 0.40; 95% confidence interval (95%CI): 0.21-0.76, Pvalue < 0.05), premenopausal (OR: 0.38; 95% CI: 0.16-0.92, Pvalue = 0.013), and postmenopausal (OR: 0.27; 95% CI: 0.10-0.78, Pvalue = 0.023).
CONCLUSION
Findings of this study suggested that higher HBI score decreased the risk of BrCa. However, further investigation is needed.
背景
乳腺癌（BrCa）是癌症相关死亡的主要原因之一。有几种导致 BrCa 的因素，包括一些与生活方式相关的可改变因素，如不健康的饮食模式，因此改变这些因素可以预防三分之一由 BrCa 引起的并发症和死亡。因此，我们决定研究健康饮料指数（HBI）与 BrCa 风险之间的关系。
方法
在这项基于医院的病例对照研究中，纳入了 253 名 BrCa 患者和 267 名非 BrCa 对照者。通过半定量食物频率问卷（FFQ）记录食物摄入量，计算 HBI 评分。此外，通过调整混杂因素的二元逻辑回归分析，评估了 HBI 与 BrCa 风险之间的关系。HBI 由 Duffey 等人建立，用于评估饮料摄入的整体质量，并识别摄入量的变化。
结果
研究参与者的平均年龄和 BMI 分别为 47.92±10.33 岁和 29.43±5.51kg/m2。BrCa 患者的腰围（WC）、初孕年龄、流产史和子女数明显高于对照组（P 值均<0.05）。与 HBI 最低四分位的人相比，HBI 最高四分位的人摄入更多的能量、碳水化合物、蛋白质、脂肪、纤维、钠、钾、钙、镁、锌、维生素 C、E、B9、水果、蔬菜、鱼和坚果，且 BMI 和 WC 较低（P 值均<0.05）。调整潜在混杂因素后，HBI 最高四分位与最低四分位相比，总体人群的 BrCa 风险显著降低（比值比（OR）：0.40；95%置信区间（95%CI）：0.21-0.76，P 值<0.05），绝经前（OR：0.38；95%CI：0.16-0.92，P 值=0.013）和绝经后（OR：0.27；95%CI：0.10-0.78，P 值=0.023）。
结论
本研究结果表明，较高的 HBI 评分降低了 BrCa 的风险。然而，还需要进一步的研究。
Zotero 插件