新型饮食和生活方式炎症指数与乳腺癌（BrCa）风险的相关性：一项病例对照研究。
Association between novel dietary and lifestyle inflammation indices with risk of breast cancer (BrCa): a case-control study.
机构信息
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Nutr J. 2022 Mar 2;21(1):14. doi: 10.1186/s12937-022-00766-0.
BACKGROUND
Pro-inflammatory diet and lifestyle factors lead to diseases related to chronically systemic inflammation. We examined the novel dietary/lifestyle indicators related to inflammation such dietary inflammation score (DIS), lifestyle inflammation score (LIS), empirical dietary inflammatory index (EDII) and, risk of Breast Cancer (BrCa) in Iranian woman.
METHODS
In this hospital-based case-control study, 253 patients with BrCa and 267 non-BrCa controls were enrolled. Food consumption was recorded to calculate the DIS, LIS and EDII using a semi-quantitative Food Frequency Questionnaire (FFQ). We estimated odds ratios (ORs) and, 95% confidence intervals for the association of the inflammatory potential with risk of these cancers using binary logistic regression models modified for the case-control design.
RESULTS
Mean ± SD of age and BMI of the study participants were 47.92 ± 10.33 years and 29.43 ± 5.51 kg/m, respectively. After adjustment for confounders, individuals in highest compared to lowest quartile of DIS and EDII had significantly higher risk of BrCa (DIS: 2.13 (1.15 - 3.92), p-trends: 0.012), EDII: 2.17 (1.12 - 4.22), p-trends: 0.024). However, no significant association was observed for LIS (P-trends: 0.374).
CONCLUSION
Findings of this study suggested that higher DIS and EDI increased the risk of BrCa, but concerning LIS, further investigation is needed.
背景
促炎饮食和生活方式因素会导致与慢性全身炎症相关的疾病。我们研究了与炎症相关的新的饮食/生活方式指标，如饮食炎症评分（DIS）、生活方式炎症评分（LIS）、经验性饮食炎症指数（EDII），以及它们与伊朗女性患乳腺癌（BrCa）的风险。
方法
在这项基于医院的病例对照研究中，纳入了 253 名 BrCa 患者和 267 名非 BrCa 对照。通过半定量食物频率问卷（FFQ）记录食物摄入量，以计算 DIS、LIS 和 EDII。我们使用基于病例对照设计的二元逻辑回归模型，估计炎症潜力与这些癌症风险之间的关联的比值比（OR）和 95%置信区间。
结果
研究参与者的平均年龄和 BMI 分别为 47.92 ± 10.33 岁和 29.43 ± 5.51 kg/m²。在调整混杂因素后，与 DIS 和 EDII 最低四分位数相比，处于最高四分位数的个体患 BrCa 的风险显著更高（DIS：2.13（1.15-3.92），p 趋势：0.012），EDII：2.17（1.12-4.22），p 趋势：0.024）。然而，LIS 没有显著相关性（p 趋势：0.374）。
结论
本研究结果表明，较高的 DIS 和 EDI 增加了患 BrCa 的风险，但关于 LIS，需要进一步研究。
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