Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Yothi Street, Bangkok, 10400, Thailand.
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
BMC Oral Health. 2024 Oct 26;24(1):1297. doi: 10.1186/s12903-024-05085-w.
Central odontogenic fibroma (COF) is a rare benign odontogenic tumor with a wide range of histopathologic features. We evaluated COF diagnosed in our institute with 16 years' experience using 2022 WHO classification.
Our archives were reviewed and cases diagnosed as COF were selected. Clinical, radiographic and microscopic features were tabulated and analyzed.
Of 13,736 specimens, six cases (0.04%) of COF were discovered. Patients ranged in age from 14 to 44 years. There were two males and four females. Maxilla and mandible were affected equally. Five cases showed radiolucent appearance (4 unilocular, 1 multilocular) and one case showed a mixed radiolucent-radiopaque pattern. Histopathologically, three cases were conventional type (2 epithelium-rich, 1 epithelium-poor). Two cases were the hybrid COF with central giant cell granuloma (CGCG) and one of which was also associated with secondary aneurysmal bone cyst (ABC). The last case with a mixed radiolucent-radiopaque pattern was the ossifying subtype.
Our results demonstrated that COF is a rare odontogenic tumor and exhibits diverse radiographic and microscopic appearances. The triphasic tumor consisting of the COF, CGCG and ABC, is reported here for the first time, while the ossifying subtype is considered the tenth case reported in the English-language literature. Oral and maxillofacial pathologists and other healthcare personnel must be aware of this rare odontogenic tumor and its variants to achieve the definite diagnosis.
Not applicable.
中央性牙源性纤维瘤（COF）是一种罕见的良性牙源性肿瘤，具有广泛的组织病理学特征。我们使用 2022 年 WHO 分类评估了本机构 16 年来诊断的 COF。
我们回顾了档案，并选择了诊断为 COF 的病例。对临床、影像学和显微镜下特征进行了列表和分析。
在 13736 个标本中，发现了 6 例（0.04%）COF。患者年龄从 14 岁到 44 岁不等。有 2 名男性和 4 名女性。上颌骨和下颌骨同样受到影响。5 例表现为透亮外观（4 例单房性，1 例多房性），1 例表现为混合透亮-不透光模式。组织病理学上，3 例为常规型（2 例富含上皮，1 例上皮较少）。2 例为混合性 COF 伴中央巨细胞肉芽肿（CGCG），其中 1 例还伴有继发性动脉瘤样骨囊肿（ABC）。最后一例具有混合透亮-不透光模式的是骨化亚型。
我们的结果表明，COF 是一种罕见的牙源性肿瘤，表现出不同的影像学和显微镜下表现。由 COF、CGCG 和 ABC 组成的三阶段肿瘤，在此首次报道，而骨化亚型被认为是在英语文献中报告的第 10 例。口腔颌面病理学家和其他医疗保健人员必须意识到这种罕见的牙源性肿瘤及其变体，以做出明确的诊断。
不适用。
