Department of Pathology, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Head Neck Pathol. 2022 Jun;16(2):494-502. doi: 10.1007/s12105-021-01390-w. Epub 2021 Oct 30.
Several attempts have been made to classify odontogenic tumors; however, the need for a uniform international classification system led the World Health Organization (WHO) to present a classification of odontogenic tumors in 1971. We aimed to evaluate the number and types of odontogenic tumors examined at the Tokyo Dental College Hospital in Japan to determine the frequency and types of odontogenic tumors, based on the 2017 WHO classification system, as this information has not been reported previously in Japan. We also compared the results of our evaluation with those reported in previous studies. We conducted a clinicopathological evaluation of odontogenic tumors examined at the Tokyo Dental College Hospital between 1975 and 2020. This included an analysis of 1089 cases (malignant, n = 10, 0.9%; benign, n = 1079, 99.1%) based on the 2017 World Health Organization Classification of Head and Neck Tumors. We identified 483 (44.3%), 487 (44.7%), and 109 (10.0%) benign epithelial odontogenic, mixed odontogenic, and mesenchymal tumors, respectively. The most common tumor types were odontoma (42.5%) and ameloblastoma (41.9%). Of the 1089 cases, 585 (53.7%) and 504 (46.3%) were male and female patients, respectively. Ameloblastoma and ameloblastic fibroma occurred more commonly in male patients, whereas odontogenic fibroma and cemento-ossifying fibroma affected female patients primarily. The age at diagnosis ranged from three to 87 (mean, 29.05) years. In 319 (29.3%) patients, the age at diagnosis ranged from 10 to 19 years. Ameloblastoma and odontoma were the most common tumor types among patients in their 20s and those aged 10-19 years, respectively. In 737 (67.7%) and 726 (66.7%) patients, the tumors were located in the mandible and posterior region, respectively. Ameloblastoma was particularly prevalent in the posterior mandible. Odontogenic tumors are rare lesions and appear to show a definite geographic variation.
已经有几次尝试对牙源性肿瘤进行分类；然而，为了建立一个统一的国际分类系统的需求，世界卫生组织（WHO）于 1971 年提出了牙源性肿瘤的分类。我们的目的是评估在日本东京齿科大学医院检查的牙源性肿瘤的数量和类型，根据 2017 年 WHO 分类系统确定牙源性肿瘤的频率和类型，因为这方面的信息以前在日本尚未报道过。我们还将我们的评估结果与以前的研究报告进行了比较。我们对 1975 年至 2020 年间在东京齿科大学医院检查的牙源性肿瘤进行了临床病理评估。这包括对 1089 例（恶性，n=10，0.9%；良性，n=1079，99.1%）基于 2017 年世界卫生组织头颈部肿瘤分类的分析。我们分别鉴定出 483（44.3%）、487（44.7%）和 109（10.0%）例良性上皮性牙源性、混合性牙源性和间质性肿瘤。最常见的肿瘤类型是牙瘤（42.5%）和造釉细胞瘤（41.9%）。在 1089 例中，585（53.7%）和 504（46.3%）例为男性和女性患者。造釉细胞瘤和牙源性纤维瘤更常见于男性患者，而牙源性纤维瘤和骨化性纤维瘤主要影响女性患者。诊断时的年龄为 3 至 87 岁（平均 29.05 岁）。在 319 例（29.3%）患者中，诊断时的年龄在 10 至 19 岁之间。造釉细胞瘤和牙瘤是 20 多岁和 10-19 岁患者中最常见的肿瘤类型。在 737 例（67.7%）和 726 例（66.7%）患者中，肿瘤分别位于下颌骨和后区。造釉细胞瘤在后下颌骨中尤为常见。牙源性肿瘤是罕见的病变，似乎表现出明显的地域差异。
