Department of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, J&K, India.
Drug Discov Ther. 2024 Nov 15;18(5):269-276. doi: 10.5582/ddt.2024.01063. Epub 2024 Oct 27.
A pandemic known as anti-microbial resistance (AMR) poses a challenge to contemporary medicine. To stop AMR's rise and quick worldwide spread, urgent multisectoral intervention is needed. This review will provide insight on new and developing treatment approaches for AMR. Future therapy options may be made possible by the development of novel drugs that make use of developments in "omics" technology, artificial intelligence, and machine learning. Vaccines, immunoconjugates, antimicrobial peptides, monoclonal antibodies, and nanoparticles may also be intriguing options for treating AMR in the future. Combination therapy may potentially prove to be a successful strategy for combating AMR. To lessen the impact of AMR, ideas like drug repurposing, antibiotic stewardship, and the one health approach may be helpful.
一种被称为抗微生物药物耐药性(AMR)的大流行病对当代医学构成了挑战。为了阻止 AMR 的上升和迅速在全球范围内传播,需要紧急采取多部门干预措施。本综述将提供有关 AMR 新的和正在发展的治疗方法的见解。新型药物的开发利用了“组学”技术、人工智能和机器学习的发展,这可能为未来的治疗选择提供可能。疫苗、免疫偶联物、抗菌肽、单克隆抗体和纳米颗粒也可能成为未来治疗 AMR 的有趣选择。联合治疗可能是对抗 AMR 的一种成功策略。为了减轻 AMR 的影响,药物再利用、抗生素管理和“同一健康”方法等想法可能会有所帮助。