He Shiji, Zhang Guanghao, Wu Changzhe, Huo Xiaolin, Zhang Lijun, Zhang Jingxi, Zhang Cheng
Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China.
School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2024 Oct 25;41(5):945-950. doi: 10.7507/1001-5515.202402007.
Transcranial direct current stimulation (tDCS) is an important method for treating mental illnesses and neurodegenerative diseases. This paper reconstructed two brain slice models based on rat brain slice staining images and magnetic resonance imaging (MRI) data respectively, and the current densities of hippocampus after cortical tDCS were obtained through finite element calculation. Subsequently, a neuron model was used to calculate the response of rat hippocampal pyramidal neuron under these current densities, and the neuronal responses of the two models under different stimulation parameters were compared. The results show that a minimum stimulation voltage of 17 V can excite hippocampal pyramidal neuron in the model based on brain slice staining images, while 24 V is required in the MRI-based model. The results indicate that the model based on brain slice staining images has advantages in precision and electric field propagation simulation, and its results are closer to real measurements, which can provide guidance for the selection of tDCS parameters and scientific basis for precise stimulation.
经颅直流电刺激（tDCS）是治疗精神疾病和神经退行性疾病的重要方法。本文分别基于大鼠脑片染色图像和磁共振成像（MRI）数据重建了两个脑片模型，并通过有限元计算获得了皮层tDCS后海马体的电流密度。随后，使用神经元模型计算这些电流密度下大鼠海马锥体神经元的反应，并比较了两个模型在不同刺激参数下的神经元反应。结果表明，基于脑片染色图像的模型中，最小刺激电压为17V时可激发海马锥体神经元，而基于MRI的模型则需要24V。结果表明，基于脑片染色图像的模型在精度和电场传播模拟方面具有优势，其结果更接近实际测量值，可为tDCS参数的选择提供指导，并为精确刺激提供科学依据。
