Sun Yu, Huang Fengliang, Zhang Hanwen, Jiang Hao, Luo Gangyin
College of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210023, P. R. China.
Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Engineering Laboratory of Advanced In Vitro Diagnostic Technology Chinese Academy of Sciences, Suzhou, Jiangsu 215163, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2024 Oct 25;41(5):1053-1061. doi: 10.7507/1001-5515.202404036.
Organoids are an model that can simulate the complex structure and function of tissues . Functions such as classification, screening and trajectory recognition have been realized through organoid image analysis, but there are still problems such as low accuracy in recognition classification and cell tracking. Deep learning algorithm and organoid image fusion analysis are the most advanced organoid image analysis methods. In this paper, the organoid image depth perception technology is investigated and sorted out, the organoid culture mechanism and its application concept in depth perception are introduced, and the key progress of four depth perception algorithms such as organoid image and classification recognition, pattern detection, image segmentation and dynamic tracking are reviewed respectively, and the performance advantages of different depth models are compared and analyzed. In addition, this paper also summarizes the depth perception technology of various organ images from the aspects of depth perception feature learning, model generalization and multiple evaluation parameters, and prospects the development trend of organoids based on deep learning methods in the future, so as to promote the application of depth perception technology in organoid images. It provides an important reference for the academic research and practical application in this field.
类器官是一种能够模拟组织复杂结构和功能的模型。通过类器官图像分析已经实现了分类、筛选和轨迹识别等功能,但仍存在识别分类和细胞跟踪准确性低等问题。深度学习算法与类器官图像融合分析是目前最先进的类器官图像分析方法。本文对类器官图像深度感知技术进行了研究梳理,介绍了类器官培养机制及其在深度感知中的应用理念,分别综述了类器官图像分类识别、模式检测、图像分割和动态跟踪这四种深度感知算法的关键进展,并对不同深度模型的性能优势进行了比较分析。此外,本文还从深度感知特征学习、模型泛化和多个评估参数等方面总结了各类器官图像的深度感知技术,展望了未来基于深度学习方法的类器官发展趋势,以推动深度感知技术在类器官图像中的应用。为该领域的学术研究和实际应用提供了重要参考。