Eroğlu Ergin, Pamuk A Erim, Özer Serdar, Önerci Tevfik Metin
Hacettepe University Faculty of Medicine, Department of Otolaryngology, Ankara, Türkiye.
Turk Arch Otorhinolaryngol. 2024 Oct 23;62(2):42-47. doi: 10.4274/tao.2024.2024-1-2.
This study aims to present the surgical and oncological long-term outcomes of patients with locally recurrent nasopharyngeal cancer (NPC) following endoscopic endonasal nasopharyngectomy (EEN).
The medical records of 11 patients who underwent EEN due to recurrent NPC were retrospectively reviewed.
The mean age of the patient cohort, consisting of 10 males (90.9%) and one female (9.1%), was 44±13.01 years at the time of initial diagnosis. Seven patients (63.7%) had local recurrence, and four patients (36.3%) had loco-regional recurrence. The mean time to first recurrence from the initial diagnosis was 40.3 months, with a 5-year overall survival (OS) rate of 72.7% and a disease-free survival (DFS) rate of 27.3%. There were no significant differences between the concurrent chemoradiotherapy (CRT) and induction chemotherapy+concurrent CRT treatment groups in terms of DFS and OS as a first-line treatment (p=0.645).
EEN is a viable alternative approach for selected cases of locally recurrent NPC, considering the morbidities associated with re-irradiation.
本研究旨在呈现接受鼻内镜下经鼻鼻咽癌切除术（EEN）的局部复发性鼻咽癌（NPC）患者的外科手术及肿瘤学长期预后。
回顾性分析11例因复发性NPC接受EEN治疗患者的病历资料。
患者队列中，男性10例（90.9%），女性1例（9.1%），初次诊断时的平均年龄为44±13.01岁。7例（63.7%）为局部复发，4例（36.3%）为局部区域复发。从初次诊断到首次复发的平均时间为40.3个月，5年总生存率（OS）为72.7%，无病生存率（DFS）为27.3%。作为一线治疗，同步放化疗（CRT）组和诱导化疗+同步CRT治疗组在DFS和OS方面无显著差异（p=0.645）。
考虑到再程放疗相关的并发症，EEN是局部复发性NPC特定病例的一种可行替代方法。
