Department of Biomedical and Clinical Sciences, Linköping University, Stair D Level 11, 58185, Linköping, Sweden.
Sci Rep. 2024 Oct 27;14(1):25638. doi: 10.1038/s41598-024-76362-5.
To compare the vibrational patterns of human and guinea pig cochleae accurately, we developed and validated a novel finite element model of the guinea pig, leveraging it to analyze vibrational patterns in the cochlea. This approach is mirrored in our examination of the human cochlear model, providing granular insights into the nuances of human bone conduction hearing. The comparative analysis reveals that the guinea pig cochlea mirrors human cochlear vibrational patterns, thus serving as an efficient proxy for exploring human cochlear function. The human mastoid and the upper region of the guinea pig's skull are recommended as the convenient and comparable sites for bone conduction stimulation. The cochlear vibration pattern encompasses a mix of rigid, rotational, and compressive motion. Significantly, the guinea pig model demonstrates robust agreement with existing experimental data and other studies, these findings are confirming the validity of the model. Our study delineates the distinct roles of the three vibration types across various frequency spectrums. At lower frequencies, rigid motion is the dominant mechanism, supplemented by rotational motion. However, at higher frequencies, the influence of rigid motion wanes, ceding prominence to rotational and compressive motions. This trend is consistently observed in both human and guinea pig models.
为了准确比较人和豚鼠耳蜗的振动模式，我们开发并验证了一种新的豚鼠有限元模型，利用该模型分析耳蜗的振动模式。我们对人耳蜗模型的检查也采用了同样的方法，深入了解了人类骨导听力的细微差别。比较分析表明，豚鼠耳蜗反映了人类耳蜗的振动模式，因此可以作为探索人类耳蜗功能的有效替代物。建议将人的乳突和豚鼠头骨的上部区域作为骨导刺激的方便和可比部位。耳蜗的振动模式包括刚性、旋转和压缩运动的混合。重要的是，豚鼠模型与现有的实验数据和其他研究具有很强的一致性，这些发现证实了模型的有效性。我们的研究描绘了三种振动类型在不同频率范围内的不同作用。在较低频率下，刚性运动是主要机制，旋转运动起辅助作用。然而，在较高频率下，刚性运动的影响减弱，旋转和压缩运动变得更为突出。这种趋势在人和豚鼠模型中都得到了一致的观察。
