Zhang Aimin, Yu Lurui, Wang Xiaoli, Huang Xiaofang, Zhang Tao, Kong Xianghao, Chi Xiaohui
Department of Stomatology, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), 317 South 1st Road, Dongying, 257091, China.
Department of Stomatology, Dongcheng Hospital, Dongying, 257091, China.
World J Surg Oncol. 2025 May 22;23(1):197. doi: 10.1186/s12957-025-03836-9.
To investigate the current situation of nosocomial infections in oral cancer patients after surgery, explore possible risk factors for nosocomial infections, screen high-risk populations for nosocomial infections after oral cancer surgery in the early stage, and provide scientific basis for the prevention and control of nosocomial infections in oral cancer patients after surgery.
201 patients with oral cancer who underwent surgery in the Department of Oral and Maxillofacial Surgery of our hospital from January 2019 to December 2023 were collected, and their clinical data were observed. Statistics on the incidence of nosocomial infections, infection sites, and pathogenic bacteria in patients undergoing oral cancer surgery. Through univariate analysis and multivariate logistic regression analysis, identify the risk factors for nosocomial infections in oral cancer patients after surgery.
This study included 201 patients undergoing oral cancer surgery, with 24 cases of nosocomial infections and a nosocomial infection rate of 11.91%. Surgical incision infection is the most common site of infection, accounting for 45.83%, followed by pulmonary infection, accounting for 33.33%. Through pathogen examination, a total of 22 strains of pathogens were found, including 14 Gram negative bacteria (63.64%) and 7 Gram positive bacteria (31.82%). The univariate analysis found that 11 items included: smoking history, drinking history, diabetes, operation duration, skin flap repair, intraoperative bleeding, preventive use of antibiotics, tracheal intubation, gastric tube retention time, venous thromboembolism on the operation day, preoperative oral scaling, which may be the risk factors for nosocomial infection after oral cancer surgery. Logistic regression analysis showed that six independent risk factors of nosocomial infection after oral cancer surgery included: diabetes, skin flap repair, intraoperative bleeding, tracheal intubation, gastric tube retention time, and venous thromboembolism on the day of operation.
Oral cancer surgery patients are at high risk of infection, and targeted monitoring of oral cancer surgery patients should be strengthened. Preventive measures should be taken for risk factors to reduce nosocomial infection rates.
调查口腔癌患者术后医院感染现状，探索医院感染可能的危险因素，早期筛查口腔癌术后医院感染的高危人群，为口腔癌患者术后医院感染的防控提供科学依据。
收集2019年1月至2023年12月在我院口腔颌面外科行手术治疗的201例口腔癌患者，观察其临床资料。统计口腔癌手术患者医院感染发生率、感染部位及病原菌。通过单因素分析和多因素logistic回归分析，确定口腔癌患者术后医院感染的危险因素。
本研究纳入201例口腔癌手术患者，发生医院感染24例，医院感染率为11.91%。手术切口感染是最常见的感染部位，占45.83%，其次是肺部感染，占33.33%。通过病原菌检查，共发现病原菌22株，其中革兰阴性菌14株（63.64%），革兰阳性菌7株（31.82%）。单因素分析发现，吸烟史、饮酒史、糖尿病、手术时长、皮瓣修复、术中出血、预防性使用抗生素、气管插管、胃管留置时间、手术日静脉血栓栓塞、术前口腔洁治11项因素可能是口腔癌术后医院感染的危险因素。logistic回归分析显示，口腔癌术后医院感染的6个独立危险因素包括：糖尿病、皮瓣修复、术中出血、气管插管、胃管留置时间、手术日静脉血栓栓塞。
口腔癌手术患者感染风险高，应加强对口腔癌手术患者的针对性监测。针对危险因素采取预防措施，降低医院感染率。
