Effect of Coronavirus Disease 2019 Pandemic and Vaccination on Menstrual Cycle Among King Saud University Students in Riyadh: A Retrospective Online Survey.

Objectives We aimed to evaluate the prevalence of menstrual cycle changes following the COVID-19 pandemic and the COVID-19 vaccination among female students at King Saud University in Riyadh, Saudi Arabia. Methods A cross-sectional retrospective study using an online questionnaire was conducted between October 2022 and December 2022. Data were collected concerning demographic variables, clinical conditions, menstrual cycle characteristics, COVID-19 infection status, and vaccination history. Results Of the 525 female students who participated in the study (mean age, 21.5 ± 3.9 years; mean body mass index, 22.7 ± 4.7 kg/m), 246 (46.9%) had tested positive for COVID-19, 15 (2.9%) had visited the emergency room, and eight (1.5%) had been hospitalized. The average duration between menstrual cycles increased significantly among the study sample (pre-pandemic, 25.9 ± 5.3 days; post-pandemic, 26.8 ± 6.7 days; p = 0.016). Pre-pandemic, 221 (42.1%) participants reported less than two days of variance between their shortest and longest cycles, as compared with 175 (33.3%) post-pandemic (p < 0.001). Regarding vaccination, 393 (74.9%) participants had received three vaccinations, and 110 (21%) had received two vaccinations. Post-vaccination, 184 (35%) participants reported no changes to their menstrual cycle, 154 (29.3%) reported less disruption, and 44 (8.4%) experienced more disrupted menstrual cycles. Conclusion This study highlights potential associations between the COVID-19 pandemic, subsequent vaccinations, and changes in menstrual patterns, which can help to elucidate the physiological and psychological effects of pandemics and vaccination campaigns on women's health. Future studies must consider biological and psychosocial factors to elucidate underlying mechanisms and causal relationships.