Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Arch Razi Inst. 2024 Apr 30;79(2):248-263. doi: 10.32592/ARI.2024.79.2.248. eCollection 2024 Apr.
In this study, the role of gummosin in improving memory in the scopolamine memory impairment model was systematically examined. Memory and learning are the most developed and complex functions of the nervous system. Learning is the acquisition of new information that occurs as a change in behavior, and memory is the ability to store and retrieve learned information. In other words, memory is a combination of various processes of information acquisition, consolidation, storage and retrieval. The processes of memory consolidation and storage are the result of a series of time-dependent neurobiological events that occur after the initial formation of memory. In addition, this fluctuation of processes related to memory storage can fully occur shortly after the initial learning experience. Memory is a direct result of learning ,as it stores and retrieves learned experiences and information. The results of our study show that scopolamine leads to impaired memory, learning and synaptic plasticity, which is associated with a change in the expression of various genes and a reduction in the number of hippocampal neurons. The disorders that occurred in the rats of the scopolamine group confirm the model used in this study to induce memory and learning deficits, which is consistent with previous studies confirming the model used to induce Alzheimer's disease. The results of the behavioral tests in this study showed that, consistent with previous work, scopolamine caused a significant increase in anxiety behavior that was associated with a decrease in time spent in the central area compared to the control group, while donepezil injection resulted in a decrease in anxiety behavior. The time spent in the central area was increased compared to the scopolamine group.
在这项研究中，系统地研究了 gummosin 在改善东莨菪碱记忆损伤模型中的记忆作用。记忆和学习是神经系统最发达和最复杂的功能。学习是行为发生变化时获得新信息的过程，而记忆是存储和检索所学信息的能力。换句话说，记忆是信息获取、巩固、存储和检索等各种过程的组合。记忆巩固和存储的过程是记忆初步形成后一系列依赖时间的神经生物学事件的结果。此外，与记忆存储相关的这些过程的波动可以在初始学习体验后不久完全发生。记忆是学习的直接结果，因为它存储和检索所学的经验和信息。我们的研究结果表明，东莨菪碱导致记忆、学习和突触可塑性受损，这与各种基因表达的变化和海马神经元数量的减少有关。东莨菪碱组大鼠出现的紊乱证实了本研究中用于诱导记忆和学习缺陷的模型与先前研究一致，这些研究证实了用于诱导阿尔茨海默病的模型。本研究行为测试的结果表明，与先前的工作一致，东莨菪碱引起明显的焦虑行为增加，与对照组相比，中央区域的时间减少，而多奈哌齐注射导致焦虑行为减少。与东莨菪碱组相比，中央区域的时间增加。
