Siscovick D S, Weiss N S, Fox N
Am J Epidemiol. 1986 Mar;123(3):499-503. doi: 10.1093/oxfordjournals.aje.a114265.
To determine if light to moderate consumption of alcohol influences the risk of primary cardiac arrest, the authors investigated 152 cases, 25-75 years of age, without prior heart disease or co-morbidity, in whom a primary cardiac arrest occurred during a 14-month period in King County, Washington state, December 1979-January 1981. Spouses of cases and those of 152 demographically similar residents of King County were interviewed to quantify average alcohol consumption over the prior year for beer, wine, and spirits combined. After adjustment for hypertension, smoking, and physical activity, light to moderate alcohol consumption was associated with a reduced risk of primary cardiac arrest. Compared to persons who were nondrinkers (less than 1 drink/month), the estimated relative risk for light drinkers (greater than or equal to 1 drink/month but less than 1 drink/day) was 0.7 (95% confidence interval, 0.5-1.0), and for moderate drinkers (1-3 drinks/day), 0.5 (95% confidence interval, 0.3-1.0). These data are consistent with the hypothesis that light to moderate alcohol consumption reduces the risk of primary cardiac arrest.
为了确定轻度至中度饮酒是否会影响原发性心脏骤停的风险,作者对152例年龄在25至75岁之间、无既往心脏病或合并症的患者进行了调查,这些患者于1979年12月至1981年1月在华盛顿州金县的14个月期间发生了原发性心脏骤停。对病例的配偶以及金县152名人口统计学特征相似的居民的配偶进行了访谈,以量化前一年啤酒、葡萄酒和烈酒的平均饮酒量。在对高血压、吸烟和体育活动进行调整后,轻度至中度饮酒与原发性心脏骤停风险降低相关。与不饮酒者(每月饮酒少于1次)相比,轻度饮酒者(每月饮酒大于或等于1次但少于每日1次)的估计相对风险为0.7(95%置信区间,0.5 - 1.0),中度饮酒者(每日饮酒1 - 3次)的估计相对风险为0.5(95%置信区间,0.3 - 1.0)。这些数据与轻度至中度饮酒可降低原发性心脏骤停风险的假设一致。