阿尔茨海默病雄性和雌性APP/PS1及APP小鼠模型的寿命。
Lifespan of male and female APP/PS1 and APP mouse models of Alzheimer's disease.
作者信息
Roberts Hannah, Fang Yimin, Quinn Kathleen, Hill Tiarra, Peck Mackenzie R, Bartke Andrzej, Hascup Kevin N, Hascup Erin R
机构信息
Neuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Dept of Neurology; Southern Illinois University School of Medicine, Springfield, IL, USA.
Dept of Internal Medicine; Southern Illinois University School of Medicine, Springfield, IL, USA.
出版信息
bioRxiv. 2024 Oct 18:2024.10.15.618508. doi: 10.1101/2024.10.15.618508.
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
阿尔茨海默病（AD）对女性的影响尤为严重，但大多数临床前研究都是以男性为中心的。我们对雄性和雌性AD小鼠模型（APP/PS1和APP）及其共享遗传背景对照（C57BL/6）进行了寿命分析。生存曲线支持不同基因型内存在显著的性别差异。最小寿命显示雄性APP/PS1小鼠年龄增加，而APP小鼠年龄减少。最大寿命显示雄性平均年龄增加。此外，性别和基因型之间的中位寿命也有所不同。本研究支持两种AD小鼠模型中存在性二态性生存现象，强调有必要对两性的机制和治疗方法进行研究。
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