Toprak Müge, Altıntaş Özgül, Sezer Özge Y, Yılmaz Tuğan Büşra
Department of Ophthalmology, Kocaeli City Hospital, Kocaeli, Turkey.
Department of Ophthalmology, Acibadem Mehmet Ali Aydınlar University, İstanbul, Turkey.
Saudi J Ophthalmol. 2024 Sep 20;38(3):257-260. doi: 10.4103/sjopt.sjopt_170_24. eCollection 2024 Jul-Sep.
To examine the level of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the pediatric patient group with keratoconus.
Patients aged 5-18 years with a diagnosis of keratoconus followed by the corneal department and children in the similar age group who were determined as controls were included in the study. Their topographies were evaluated. In both groups, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) were measured.
The study group consisted of children aged 15 ± 1.4 years and the control group 13 ± 1.3 years of age. The mean central corneal thickness of the patients in the patient group was 445.64 μm, and in the control group was 532.25 μm. The NLR was 3.37 ± 1.04 in the patient group and 2.31 ± 0.82 in the control group. The PLR was significantly increased in the KC group (147.54 ± 41.36) than in the control group (118.71 ± 27.11) ( = 0.042). MPV in the patient group was 12.18 ± 2.76 and 7.00 ± 1.37 in the control group. This value was found to be statistically significant ( = 0.047) when the control group and the patient group were compared.
Platelet/lymphocyte ratio and mean platelet volume, which are thought to be new markers of systemic inflammation, may be new indices in keratoconus in pediatric patients.
检测圆锥角膜患儿组中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值水平。
纳入角膜科确诊为圆锥角膜的5至18岁患者以及年龄相仿的对照组儿童。评估他们的角膜地形图。两组均测量中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）及平均血小板体积（MPV）。
研究组患儿年龄为15±1.4岁，对照组为13±1.3岁。患者组患者的平均中央角膜厚度为445.64μm，对照组为532.25μm。患者组NLR为3.37±1.04，对照组为2.31±0.82。圆锥角膜组（KC组）的PLR（147.54±41.36）显著高于对照组（118.71±27.11）（P = 0.042）。患者组MPV为12.18±2.76，对照组为7.00±1.37。对照组与患者组比较时，该值具有统计学意义（P = 0.047）。
血小板/淋巴细胞比值及平均血小板体积被认为是全身炎症的新标志物，可能是圆锥角膜患儿的新指标。
