Wästerström S A, Bredberg G, Lindquist N G, Lyttkens L, Rask-Anderson H
Am J Otol. 1986 Jan;7(1):11-8.
Ototoxic drugs of the aminoglycoside type have been shown to accumulate to melanin, suggesting a possible mechanism for their ototoxicity. The present study was undertaken by combining electrophysiologic and morphologic methods to investigate whether the ototoxicity of kanamycin is different in pigmented and albino guinea pigs. In pigmented animals a kanamycin dose of 200 mg per kilogram of body weight per day resulted in hearing loss together with loss of both inner and outer hair cells. The albino animals in the same dose group showed significantly less hearing loss and hair cell degeneration. With daily doses of 20 and 60 mg/kg/day, no difference in ototoxicity was found between the pigmented and albino animals. The results support the hypothesis that affinity of kanamycin to inner ear melanin might be responsible for the difference in ototoxicity between albino and pigmented guinea pigs.
氨基糖苷类耳毒性药物已被证明会在黑色素中蓄积，这提示了其耳毒性的一种可能机制。本研究采用电生理和形态学方法相结合，以探究卡那霉素对有色豚鼠和白化豚鼠的耳毒性是否存在差异。在有色动物中，每天每千克体重200毫克的卡那霉素剂量会导致听力损失以及内、外毛细胞的丧失。相同剂量组的白化动物听力损失和毛细胞退化明显较少。每日剂量为20和60毫克/千克/天时，有色和白化动物之间未发现耳毒性差异。这些结果支持了以下假设：卡那霉素与内耳黑色素的亲和力可能是白化豚鼠和有色豚鼠耳毒性差异的原因。
