Du X P
First Affiliated Hospital, Hubei Medical College, Wuhan.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1993;28(1):14-6, 58.
In order to clarify the relationship between ototoxicity of aminoglucoside and inner ear melanin, we have undergone observations on the cochleas of albino and pigmented guinea pigs with surface preparation, paraffin section. SEM and ECochG following chronic administration of kanamycin. The damage in the pigmented animal was more serious than that of the albino ones. It seems that the cochlea of the pigmented animal is more susceptible to kanamycin than that of the albino ones. It suggests that melanin may be implicated in the ototoxicity of aminoglucoside antibiotics that might be due to its capacity to take and accumulate the drug.
为阐明氨基糖苷类药物的耳毒性与内耳黑色素之间的关系，我们通过表面制备、石蜡切片、扫描电子显微镜（SEM）和电耳蜗图（ECochG），对长期给予卡那霉素的白化豚鼠和有色豚鼠的耳蜗进行了观察。有色动物的损伤比白化动物更严重。似乎有色动物的耳蜗比白化动物的耳蜗对卡那霉素更敏感。这表明黑色素可能与氨基糖苷类抗生素的耳毒性有关，这可能是由于其摄取和积累药物的能力所致。
