Anqing Municipal Hospital, Anqing City, Anhui Province, China.
Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, China.
Medicine (Baltimore). 2024 Oct 11;103(41):e39915. doi: 10.1097/MD.0000000000039915.
The coronavirus disease 2019 (COVID-19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 has posed a significant threat to global health since its outbreak in early 2020. Various thrombotic complications have been reported in COVID-19 cases. This study aims to investigate the incidence of various types of thromboses during the COVID-19 pandemic, and explore the potential correlation between the number of COVID-19 infections and occurrence of thrombosis. The present retrospective, single-center study recorded the number of new cases with various types of thromboembolism among all hospital admissions between 2019 and 2023 in a single center. The correlation between the number of total thromboembolism cases and number of inpatients who tested positive for COVID-19 was assessed using Spearman rank correlation coefficient. A total of 3926 thromboembolism cases were recorded in men, while 3657 cases were reported in women. The total number of new thromboembolism cases among all inpatients annually increased from 2019 to 2022, and reached a peak during the "full liberalization" period from December 2022 to January 2023. The most substantial increase was observed in microthrombosis cases, followed by venous and arterial thrombosis cases. In addition, thromboembolism primarily occurred in the lower extremities, followed by the abdomen. The fewest cases were observed in the upper extremities. Furthermore, the correlation coefficient between the total number of thromboembolism cases and number of COVID-19-positive patients between January 2020 and June 2023 was 0.501 (P = .001). The number of thromboembolism cases among all inpatients was correlated to the number of COVID-19-positive patients during the pandemic. Early thromboembolism prophylaxis and thrombotic complications monitoring should be considered for hospitalized patients, when necessary.
新型冠状病毒病 2019（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2 引起的肺炎，自 2020 年初爆发以来，对全球健康构成了重大威胁。COVID-19 病例中已报告各种血栓并发症。本研究旨在调查 COVID-19 大流行期间各种类型血栓形成的发生率，并探讨 COVID-19 感染数量与血栓形成发生之间的潜在相关性。本回顾性、单中心研究记录了 2019 年至 2023 年期间，在一家单中心所有住院患者中新发生的各种类型血栓栓塞的例数。使用 Spearman 秩相关系数评估总血栓栓塞病例数与 COVID-19 阳性住院患者数之间的相关性。共记录了 3926 例男性血栓栓塞病例，3657 例女性血栓栓塞病例。每年所有住院患者中新发血栓栓塞例数从 2019 年增加到 2022 年，在 2022 年 12 月至 2023 年 1 月的“全面放开”期间达到高峰。其中微血栓病例增加最多，其次是静脉和动脉血栓病例。此外，血栓栓塞主要发生在下肢，其次是腹部。上肢最少。此外，2020 年 1 月至 2023 年 6 月间，总血栓栓塞病例数与 COVID-19 阳性患者数之间的相关系数为 0.501（P=0.001）。大流行期间，所有住院患者的血栓栓塞病例数与 COVID-19 阳性患者数相关。必要时，应考虑对住院患者进行早期血栓栓塞预防和血栓并发症监测。
