Yue Qiang, Cao Zilong, Li Rui, Wang Yunzhang, Rui Shu, Yin Ningbei, Liu Liqiang
The Department of Perineal Plastic Surgery and Gender Reshaping of Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People's Republic of China.
The Department of Cleft Lip and Palate of Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People's Republic of China.
Aesthetic Plast Surg. 2025 Feb;49(4):1145-1153. doi: 10.1007/s00266-024-04479-z. Epub 2024 Oct 28.
Physiological oxygen concentration in adipose tissue is closely linked to metabolic disorders such as chronic inflammation and insulin resistance. However, the nature of the variation in the oxygen levels of adipose tissue with body mass index (BMI) and depths of abdominal fat remain unclear. Therefore, this study aimed to elucidate the patterns of oxygen concentration in adipose tissue layers according to BMI.
In this study, patients undergoing abdominal fat removal surgery were divided into the normal-weight (NW) or overweight-obese (OW) groups based on their BMI. Oxygen concentrations in abdominal superficial (sSAT) and deep subcutaneous adipose tissue (dSAT) were measured. The oxygen consumption rate, mean cell area, and capillary density in both tissue layers were compared between the two groups. Furthermore, the interaction between these three variables, BMI, and adipose tissue oxygen concentration, was analyzed using linear regression.
A total of 42 patients were recruited in this study and we observed that oxygen concentration in the sSAT was significantly lower than in the dSAT, irrespective of BMI. In terms of the oxygen concentration in the dSAT, OW's was significantly lower than that of NW's. Linear regression analysis revealed a significant correlation between dSAT oxygen concentration and BMI, mean adipocyte area, and vascular density.
Individuals who are obese have significantly lower oxygen levels in the deep abdominal adipose tissue, and this is influenced by BMI, adipocyte area, and capillary density.
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脂肪组织中的生理氧浓度与慢性炎症和胰岛素抵抗等代谢紊乱密切相关。然而，脂肪组织氧水平随体重指数（BMI）和腹部脂肪深度变化的本质仍不清楚。因此，本研究旨在阐明根据BMI划分的脂肪组织层中的氧浓度模式。
在本研究中，接受腹部脂肪切除手术的患者根据BMI分为正常体重（NW）组或超重肥胖（OW）组。测量腹部浅表（sSAT）和深部皮下脂肪组织（dSAT）中的氧浓度。比较两组中两个组织层的氧消耗率、平均细胞面积和毛细血管密度。此外，使用线性回归分析这三个变量、BMI和脂肪组织氧浓度之间的相互作用。
本研究共招募了42名患者，我们观察到无论BMI如何，sSAT中的氧浓度均显著低于dSAT中的氧浓度。就dSAT中的氧浓度而言，OW组显著低于NW组。线性回归分析显示dSAT氧浓度与BMI、平均脂肪细胞面积和血管密度之间存在显著相关性。
肥胖个体深部腹部脂肪组织中的氧水平显著较低，这受到BMI、脂肪细胞面积和毛细血管密度的影响。
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