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2023年阿根廷布宜诺斯艾利斯一家三级医院蚊媒疾病患儿的临床和流行病学特征

Clinical and epidemiological characteristics of children with mosquito-borne diseases in a tertiary hospital, Buenos Aires, Argentina, 2023.

作者信息

Deregibus María I, Botana Rodríguez Claudia B, Berberian Griselda, Pérez Guadalupe, Borgnia Daniela, Rovetta Mariano, Lavaze Romina, Bagnara Eliana I, Martínez María B, Zlotogora Ana, Carrafancq Juliana, Vázquez Mercedes, Melgarejo Miguel, Jaciuk Pablo, Amoedo Diego I

机构信息

Low Risk Sector; Pediatrics Hospital. S.A.M.I.C. Prof. Dr. Juan P. Garrahan, City of Buenos Aires, Argentina.

Epidemiology and Infectious Diseases Service; Pediatrics Hospital. S.A.M.I.C. Prof. Dr. Juan P. Garrahan, City of Buenos Aires, Argentina.

出版信息

Arch Argent Pediatr. 2025 Apr 1;123(2):e202410415. doi: 10.5546/aap.2024-10415.eng. Epub 2024 Oct 31.

DOI:10.5546/aap.2024-10415.eng
PMID:39467166
Abstract

Introduction. Arboviruses, such as dengue and chikungunya, have caused multiple epidemics in the Americas. They are transmitted through mosquito bites; Aedes aegypti is their main vector. As of January 2023, coinciding with the fourth dengue outbreak in Argentina, a new dengue outbreak was observed in the Americas, coincident with the presence of chikungunya. We considered it essential to describe the demographic, epidemiological, clinical, and evolutionary characteristics of dengue/chikungunya patients seen in a tertiary pediatric hospital in the Autonomous City of Buenos Aires in 2023. Population and methods. Descriptive, observational, retrospective cohort study. Includes children of 0 to 16 years with compatible symptomatology and positive PCR or IgM for dengue or chikungunya from February 1, 2023, through May 31, 2023. Results. A total of 168 patients were identified, with a median age of 138 months (IQR: 107-164). The diagnosis of dengue was confirmed in 140 and of chikungunya in 28. Ninety-eight percent were autochthonous cases. In 85% of the cases, PCR was used to make the virological diagnosis of dengue, and in the remaining 15%, IgM was used. PCR diagnosed chikungunya in 61% of cases. Patients with dengue fever had a longer duration of fever, abdominal pain, headache, myalgias, and retroocular pain. Exanthema and arthralgias were associated with chikungunya. Conclusions. The epidemiology of mosquito-borne diseases is dynamic and is related to what happens in the rest of the countries of South America; knowledge of it is essential to predict the etiological risk and prevalence.

摘要

引言。登革热和基孔肯雅热等虫媒病毒在美洲引发了多次疫情。它们通过蚊虫叮咬传播;埃及伊蚊是主要传播媒介。截至2023年1月,在阿根廷第四次登革热疫情爆发的同时,美洲出现了新的登革热疫情,且与基孔肯雅热疫情并存。我们认为有必要描述2023年在布宜诺斯艾利斯自治市一家三级儿科医院就诊的登革热/基孔肯雅热患者的人口统计学、流行病学、临床和进化特征。

研究对象与方法。描述性、观察性、回顾性队列研究。纳入2023年2月1日至2023年5月31日出现符合症状且登革热或基孔肯雅热PCR检测或IgM检测呈阳性的0至16岁儿童。

结果。共确定168例患者,中位年龄为138个月(四分位间距:107 - 164)。确诊登革热140例,基孔肯雅热28例。98%为本地病例。85%的登革热病例通过PCR进行病毒学诊断,其余15%使用IgM检测。61%的基孔肯雅热病例通过PCR确诊。登革热患者发热、腹痛、头痛、肌痛和眼球后疼痛持续时间更长。皮疹和关节痛与基孔肯雅热有关。

结论。蚊媒疾病的流行病学是动态变化的,与南美洲其他国家的情况相关;了解其情况对于预测病因风险和流行情况至关重要。

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