Xu Jiangmin, Liu Zhitao, Jiang Danying, Xu Yuqing, Chen Xinyu, Rao Yuchun
College of Life Sciences, Zhejiang Normal University, Jinhua 321004, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2024 Oct 25;40(10):3321-3336. doi: 10.13345/j.cjb.240256.
The xanthine dehydrogenase (XDH), a molybdenum-containing oxidoreductase belonging to the molybdenum hydroxylase flavoprotein family, has been identified in a variety of eukaryotes, bacteria, and archaea. XDH catalyzes the conversion of xanthine and hypoxanthine to uric acid, which then undergoes further reactions to form allantoin and allantoic acid. Studies have shown that XDH plays a role in various metabolic processes, including purine metabolism, nitrogen metabolism, hormone metabolism, reactive oxygen species metabolism, and responses to biotic and abiotic stresses. Here, we introduced the structural features, metabolic pathways, and biological functions of XDH. In addition, we summarized the research progress in XDH to give insights into the molecular mechanism of purine metabolism in plants and prospected the application of XDH, with the aim to facilitate future research on the growth, development, and stress resistance of crops.
黄嘌呤脱氢酶（XDH）是一种含钼的氧化还原酶，属于钼羟化酶黄素蛋白家族，已在多种真核生物、细菌和古细菌中被鉴定出来。XDH催化黄嘌呤和次黄嘌呤转化为尿酸，尿酸随后进一步反应形成尿囊素和尿囊酸。研究表明，XDH在多种代谢过程中发挥作用，包括嘌呤代谢、氮代谢、激素代谢、活性氧代谢以及对生物和非生物胁迫的响应。在此，我们介绍了XDH的结构特征、代谢途径和生物学功能。此外，我们总结了XDH的研究进展，以深入了解植物嘌呤代谢的分子机制，并对XDH的应用进行了展望，旨在促进未来对作物生长、发育和抗逆性的研究。
