Ben Abdelhafidh Hiba, Ben Rejeb Oumayma, Rouis Nour, Bannour Badra, Fathallah Neila, Bannour Imen
University of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, Tunisia.
University of Sousse, Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
Radiol Case Rep. 2024 Oct 18;20(1):158-161. doi: 10.1016/j.radcr.2024.09.133. eCollection 2025 Jan.
Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development. We present a rare case of femoral agenesis observed in a woman who experienced a failed medical abortion with Misoprostol (Cytotec®), highlighting the need for a better understanding of the risks associated with fetal exposure to this drug and the implementation of rigorous follow-up measures after its use.
米索前列醇是前列腺素E1的合成类似物，常用于妇科，特别是与米非司酮联合用于选择性堕胎。尽管其使用广泛，但米索前列醇在药物流产失败病例中的潜在致畸作用在医学文献中尚未得到充分探讨。严重先天性畸形虽然罕见，但已有报道，这引发了人们对该药物对胎儿发育影响的担忧。我们报告了一例罕见的股缺如病例，该病例发生在一名使用米索前列醇（喜克溃®）药物流产失败的女性身上，强调了更好地了解胎儿接触该药物相关风险以及在使用后实施严格随访措施的必要性。
