el-Refaey H, Templeton A
Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Scotland, UK.
Hum Reprod. 1995 Feb;10(2):475-8. doi: 10.1093/oxfordjournals.humrep.a135965.
The combination of mifepristone (RU486) and prostaglandin is effective in the induction of abortion in the second trimester. The optimal regimen is still under development, but is likely to be characterized by a short induction-to-abortion interval, low incidence of side-effects and high acceptability. We have investigated further whether misoprostol, a synthetic prostaglandin E1 analogue, can reliably induce second trimester abortion in 70 women pre-treated with mifepristone, and whether different routes of administration affect the induction-to-abortion interval. Abortion was achieved in 97% [95% confidence interval (CI) 90-100%] of cases without resort to other prostaglandin agents. The mean induction abortion time for the studied population was 6.4 h (95% CI 5.6-7.0 h). No significant difference was found between two different routes of administration, namely vaginal versus a combination of vaginal and oral. Misoprostol has a number of advantages over other prostaglandin preparations. We recommend that, following pre-treatment with mifepristone, misoprostol is used as the prostaglandin of choice to induce abortion in the second trimester.
米非司酮（RU486）与前列腺素联合使用在中期妊娠引产中是有效的。最佳方案仍在研发中，但可能具有引产至流产间隔短、副作用发生率低和可接受性高的特点。我们进一步研究了米索前列醇（一种合成的前列腺素E1类似物）能否在70例预先用米非司酮治疗的妇女中可靠地诱导中期妊娠流产，以及不同给药途径是否会影响引产至流产的间隔时间。97%[95%置信区间（CI）90 - 100%]的病例在未使用其他前列腺素制剂的情况下成功流产。研究人群的平均引产至流产时间为6.4小时（95%CI 5.6 - 7.0小时）。两种不同给药途径，即阴道给药与阴道和口服联合给药之间未发现显著差异。米索前列醇相对于其他前列腺素制剂具有许多优势。我们建议，在米非司酮预处理后，米索前列醇用作中期妊娠引产的首选前列腺素。
