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瑞香素抑制 JNK/STAT3/NF-κB 通路介导的肺腺癌细胞 A549 的迁移和克隆形成。

Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.

机构信息

Department of Clinical Laboratory, Jiangxi Provincial People's Hospital & The first Affiliated Hospital of Nanchang Medical College, Nanchang, China.

出版信息

Cell Adh Migr. 2024 Dec;18(1):27-37. doi: 10.1080/19336918.2024.2418049. Epub 2024 Oct 29.

DOI:10.1080/19336918.2024.2418049
PMID:39469948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540088/
Abstract

Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism. The anti-tumor effects of daphnetin on the proliferation, clone formation, migration, and invasion of A549 lung adenocarcinoma cells were investigated. The results showed that daphnetin inhibited the proliferation, colony formation, migration, and invasion of A549 cells through the MAPK/STAT3/NF-KB pathway, and mainly inhibited the clonal formation and migration of A549 cells through the JNK pathway. These results provide a new research direction and theoretical basis for the use of daphnetin in the inhibition of lung adenocarcinoma.

摘要

瑞香素是从瑞香属植物中分离得到的香豆素衍生物，具有抗肿瘤作用。MAPK、STAT3 和 NF-κB 信号通路与肺癌的发病机制密切相关。为探讨瑞香素对肺腺癌细胞 A549 的抑制作用及其机制。研究了瑞香素对肺腺癌细胞 A549 增殖、克隆形成、迁移和侵袭的影响。结果表明，瑞香素通过 MAPK/STAT3/NF-κB 通路抑制 A549 细胞的增殖、集落形成、迁移和侵袭，主要通过 JNK 通路抑制 A549 细胞的克隆形成和迁移。这些结果为瑞香素在抑制肺腺癌中的应用提供了新的研究方向和理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/fef0424aa212/KCAM_A_2418049_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/3e07959bdf05/KCAM_A_2418049_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/83d33d1d07e3/KCAM_A_2418049_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/8a97dcf1cfb4/KCAM_A_2418049_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/6dcbd5e7d0c0/KCAM_A_2418049_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/7989e1b4b59c/KCAM_A_2418049_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/2ec4ee53d87b/KCAM_A_2418049_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/04909bf35973/KCAM_A_2418049_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/fef0424aa212/KCAM_A_2418049_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/3e07959bdf05/KCAM_A_2418049_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/83d33d1d07e3/KCAM_A_2418049_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/8a97dcf1cfb4/KCAM_A_2418049_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/6dcbd5e7d0c0/KCAM_A_2418049_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/7989e1b4b59c/KCAM_A_2418049_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/2ec4ee53d87b/KCAM_A_2418049_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/04909bf35973/KCAM_A_2418049_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb9/11540088/fef0424aa212/KCAM_A_2418049_F0008_OC.jpg

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本文引用的文献

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Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway.瑞香素通过上调 CD38 抑制 MAPK/NF-κB/NLRP3 通路缓解脂多糖诱导的肺损伤。
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