Mitrofanov A A, Shenin Iu D, Mitrofanova V G
Antibiot Med Biotekhnol. 1986 Jan;31(1):13-6.
Levorin, an aromatic heptaenic antibiotic and sodium nitrite in solution of acetic acid formed a diazo compound. In the diazo reaction this compound interacted with beta-napthol or H-acid. The resulting azo compounds were readily soluble in organic solvents. In water their nitrites formed true solutions. The biological activity of the azo levorins was 100-200 times lower than that of the initial levorin. The physico-chemical characteristics of the azo levorins are presented.
利佛菌素，一种芳香族七烯抗生素，与亚硝酸钠在醋酸溶液中形成了一种重氮化合物。在重氮反应中，该化合物与β-萘酚或H-酸相互作用。生成的偶氮化合物易溶于有机溶剂。在水中，它们的亚硝酸盐形成真溶液。偶氮利佛菌素的生物活性比初始利佛菌素低100 - 200倍。文中介绍了偶氮利佛菌素的物理化学特性。
