Shenin Iu D, Filippova A I
Antibiot Med Biotekhnol. 1987 May;32(5):333-7.
The products of retroaldol splitting and azonolysis of isolevorin A2 resulting from UV irradiation of levorin A2 solutions were studied in comparison with the products of the same chemical transformations of the initial levorin A2. The findings enabled to classify isolevorin A2 as a transheptaen. Investigation of the products of retroaldol splitting of isolevorin resulting from chemical isomerization suggested that along with cys- and trans-conversions during chemical isomerization there took place chloroform transference with formation of a branched polyen. NMR spectroscopy revealed 2 free carbonyls in the isolevorin A2 molecule. The other 2 formed the hemiketal rings.
对异左霉素A2溶液进行紫外线照射后，研究了异左霉素A2的逆羟醛缩合裂解产物和氮杂分解产物，并与初始左霉素A2相同化学转化的产物进行了比较。这些发现使得异左霉素A2能够被归类为反式七烯。对化学异构化产生的异左霉素逆羟醛缩合裂解产物的研究表明，在化学异构化过程中，除了顺式和反式转化外，还发生了氯仿转移并形成了支链多烯。核磁共振光谱显示异左霉素A2分子中有2个游离羰基。另外2个形成了半缩酮环。
