Peshkova N A
Antibiotiki. 1978 Oct;23(10):906-10.
The results of the study of the pharmacological properties of the preparation of 5 per cent levorin solution in 40 per cent sodium salicylate solution are presented. The toxicity of levorin contained in the preparation was studied in the acute experiment on its intraperitoneal administration to mice. It did not differ from that of sodium levorin. In concentration of 5000 units/ml with respect to levorin the preparation did not change the motion speed of the ciliated epithelium cilia of the frog esophagus when used in the form of aerosol. Innocuousness of the preparation used repeatedly for inhalation in the form of aerosol was studied. The preparation was innocuous in the doses 12 and 24 times higher than the therapeutic ones. When applied locally on the skin and the eye conjunctiva for 16-20 days the preparation in the respective pharmaceutical forms was innocuous. Absorption and distribution of the water-soluble levorin in mice treated with the drug intraperitoneally or inhalationally was studied. It was found that levorin contained in the preparation circulated in the blood in bacteriostatic concentrations after its intraperitoneal administration for 8 hours. When used as inhalation in the form of aerosol levorin was detected in the lungs and urine and circulated in concentrations exceeding the bacteriostatic ones for 12 hours.
本文展示了5%左菌素溶液在40%水杨酸钠溶液中的制剂药理特性研究结果。通过对小鼠腹腔注射该制剂，在急性实验中研究了制剂中所含左菌素的毒性。其毒性与左菌素钠无异。以气雾剂形式使用时，该制剂中左菌素浓度为5000单位/毫升时，并未改变青蛙食管纤毛上皮纤毛的运动速度。研究了以气雾剂形式反复吸入使用该制剂的无害性。该制剂在高于治疗剂量12倍和24倍的剂量下是无害的。当以相应剂型局部应用于皮肤和眼结膜16 - 20天时，该制剂是无害的。研究了经腹腔注射或吸入给药后，水溶性左菌素在小鼠体内的吸收和分布情况。结果发现，腹腔注射该制剂8小时后，制剂中的左菌素以抑菌浓度在血液中循环。当以气雾剂形式吸入使用时，在肺部和尿液中检测到左菌素，其浓度超过抑菌浓度并循环了12小时。
