Department of Breast Surgery, Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan Clinical Research Center for Breast Cancer, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of VIP In-Patient Ward, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Medicine (Baltimore). 2024 Oct 25;103(43):e40274. doi: 10.1097/MD.0000000000040274.
Macrophages are key regulators of the inflammatory and innate immune responses. Researchers have shown that aberrant expression of macrophages contributes to the development of abdominal aortic aneurysms (AAA). However, a comprehensive bibliometric analysis exploring the research status and knowledge mapping of this area is lacking. This study aimed to explore the research status, knowledge mapping and hotspots of macrophages in AAA research from a bibliometric perspective.
In this study, we retrieved articles published between 2000 and 2022 on macrophages associated with AAA research from the Web of Science Core Collection (WoSCC) database. The retrieved literature data were further analyzed using Citespace and VOSviewer software.
A total of 918 qualified publications related to AAA-associated macrophages were retrieved. The number of publications in this field has been increasing annually. China and the United States were the 2 main drivers in this field, contributing to more than 64% of the publications. In addition, the US had the most publications, top institutions, and expert researchers, dominating in research on macrophages in AAA. The Harvard University was the most productive institution, with 60 publications. The journal with the most publications was Arteriosclerosis, Thrombosis, and Vascular Biology (86). Daugherty Alan was the most prolific author (28 publications) and he was also the most cited co- author. Furthermore, the exploration of established animal models, macrophage-related inflammatory-microenvironment, macrophage-related immune mechanism, clinical translation and molecular imaging research remained future research directions in this field.
Our findings offered new insights for scholars in this field. They will help researchers explore new directions for their work.
巨噬细胞是炎症和先天免疫反应的关键调节者。研究人员表明，巨噬细胞的异常表达有助于腹主动脉瘤（AAA）的发展。然而，缺乏对该领域研究现状和知识图谱的全面文献计量分析。本研究旨在从文献计量学的角度探讨巨噬细胞在 AAA 研究中的研究现状、知识图谱和热点。
本研究从 Web of Science 核心合集（WoSCC）数据库中检索了 2000 年至 2022 年间与 AAA 相关的巨噬细胞研究的相关文章。使用 Citespace 和 VOSviewer 软件对检索到的文献数据进行了进一步分析。
共检索到 918 篇与 AAA 相关的巨噬细胞相关的合格文献。该领域的文献数量呈逐年递增趋势。中国和美国是该领域的 2 个主要驱动力，贡献了超过 64%的文献。此外，美国发表的文献数量、顶尖机构和专家研究人员最多，在 AAA 中巨噬细胞的研究方面占据主导地位。哈佛大学是最具生产力的机构，发表了 60 篇论文。发表文献最多的期刊是《动脉硬化、血栓形成和血管生物学》（86 篇）。高产作者是 Daugherty Alan（28 篇），他也是被引最多的合著者。此外，建立动物模型、巨噬细胞相关炎症微环境、巨噬细胞相关免疫机制、临床转化和分子成像研究的探索仍然是该领域未来的研究方向。
我们的研究结果为该领域的学者提供了新的见解。它们将帮助研究人员探索他们工作的新方向。
