Piepgras D G, Sundt T M, Marsh W R, Mussman L A, Fode N C
Ann Surg. 1986 Feb;203(2):205-13. doi: 10.1097/00000658-198602000-00015.
Among 1992 patients undergoing carotid endarterectomy from January 1972 through December 1984, 57 operations were performed in 51 patients for recurrent carotid stenosis. Thirty-four of these cases had undergone initial surgery at this institution while 23 had endarterectomy elsewhere. Fifty-two of the 57 operations were for symptomatic disease while five were for evidence of a progressing lesion. All operative procedures were monitored with intracerebral blood flow measurements and continuous electroencephalograms. Twenty-three patients required intraoperative shunting. There were no complications related to shunt usage or to the period of temporary occlusion in patients who did not require shunting. Recurrent stenosis was related to intimal hyperplasia in 14 cases, recurrent atherosclerosis with interluminal thrombi or degenerated plaque in 27, unexplained soft thrombus in eight, proximal scarring in six, and to aneurysms in two. Intimal hyperplasia was the most common cause for restenosis within 2 years from the date of surgery and developed earlier in patients with a primary closure than in patients closed with a patch graft. The operative complication rate was 10.5% or 4 times the risk of surgery for primary atherosclerosis at this institution. Complications were attributed primarily to intraoperative and postoperative thromboembolic events related to apparent increased thrombogenicity of these vessels. The highest complication rate occurred in the group of patients undergoing surgery for thrombotic material in the internal carotid artery, either primary or with underlying atherosclerosis. There were no neurological complications in the group with myointimal hyperplasia. The authors' experience suggests that on-lay patch grafting without endarterectomy should be used in patients with myointimal hyperplasia. Patients with complicated recurrent atherosclerosis can be treated with endarterectomy and patch grafting, but interposition vein grafts should be considered in cases in which the vessels are extensively damaged by the recurrent plaque or with an unexplained thrombus at the site of previous endarterectomy.
在1972年1月至1984年12月期间接受颈动脉内膜切除术的1992例患者中,51例患者进行了57次手术以治疗复发性颈动脉狭窄。其中34例患者在此机构接受了初次手术,23例在其他地方接受了内膜切除术。57次手术中有52次是针对有症状的疾病,5次是针对病变进展的证据。所有手术过程均通过脑血流量测量和连续脑电图进行监测。23例患者术中需要分流。在不需要分流的患者中,没有与分流使用或临时闭塞期相关的并发症。复发性狭窄与14例内膜增生、27例伴有腔内血栓或退化斑块的复发性动脉粥样硬化、8例不明原因的软血栓、6例近端瘢痕形成以及2例动脉瘤有关。内膜增生是手术后2年内再狭窄的最常见原因,在一期缝合的患者中比用补片移植缝合的患者出现得更早。手术并发症发生率为10.5%,是该机构原发性动脉粥样硬化手术风险的4倍。并发症主要归因于与这些血管明显增加的血栓形成倾向相关的术中及术后血栓栓塞事件。在内颈动脉有血栓物质的患者组中,无论是原发性还是伴有潜在动脉粥样硬化,并发症发生率最高。内膜肌增生组没有神经并发症。作者的经验表明,对于内膜肌增生患者,应采用不进行内膜切除术的外置补片移植术。复杂复发性动脉粥样硬化患者可采用内膜切除术和补片移植术治疗,但对于血管因复发性斑块广泛受损或既往内膜切除术部位有不明原因血栓的病例,应考虑采用间置静脉移植术。