Li Qiuyi, Liu Yongzhe, Zhao Delu, Yang Yupu, Liu Qibo, Zhang Yujun, Wu Junling, Dong Zheqin
Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, China.
Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, China.
Dent Mater. 2025 Jan;41(1):16-27. doi: 10.1016/j.dental.2024.10.010. Epub 2024 Oct 29.
Stress concentration and excessive wear on the opposite jaw teeth are the main problems that lead to the failure of all-ceramic crown restoration. The objectives of this study were to: (1) Synthesize the biomimetic gradient zirconia/resin composites. (2) Control the porosity and structure so that the mechanical properties of the biomimetic gradient zirconia/resin composites are close to enamel and dentin.
Biomimetic uniform zirconia scaffolds with different widths (1.6 mm, 1.8 mm, 1.9 mm, 2.0 mm, 2.2 mm) and Biomimetic gradient (1.6 mm-2.2 mm) zirconia scaffolds were designed using 3DMax and Magics, fabricated by digital light processing 3D printing, and then infiltrated into dental resin for mechanical testing, finite element simulation and cytotoxicity testing.
Results show that the ceramic-polymer composites exhibit a significant enhancement in strength (1.37-fold increase) and toughness (2.08-fold increase) compared to zirconia ceramic scaffold (P < 0.05), highlighting the effectiveness of our structural design. In addition, the gradient design further improves the mechanical strength of the composites. Notably, the gradient composite crown exhibits a bending strength of 138.3 (±16.7) MPa, a toughness of 9.0 (±0.5) MJ/m³, and a compressive strength of 113.7 (±2.6) MPa, values that are comparable to those of natural enamel and dentin, and shows good biosafety.
Biomimetic gradient zirconia/dental resin materials were precisely fabricated through a series of studies, which is expected to further improve the clinical treatment effect. At the same time, the strategic design also provides new ideas for the performance improvement of other dental materials.
Gradient zirconia/resin composite materials with mechanical properties matching natural teeth were precisely fabricated, and are expected to significantly improve clinical treatment outcomes. Additionally, the strategic design provides new insights for enhancing the performance of other dental materials.
应力集中和对颌牙过度磨损是导致全瓷冠修复失败的主要问题。本研究的目的是：（1）合成仿生梯度氧化锆/树脂复合材料。（2）控制孔隙率和结构，使仿生梯度氧化锆/树脂复合材料的力学性能接近牙釉质和牙本质。
使用3DMax和Magics设计不同宽度（1.6毫米、1.8毫米、1.9毫米、2.0毫米、2.2毫米）的仿生均匀氧化锆支架和仿生梯度（1.6毫米 - 2.2毫米）氧化锆支架，通过数字光处理3D打印制造，然后渗入牙科树脂进行力学测试、有限元模拟和细胞毒性测试。
结果表明，与氧化锆陶瓷支架相比，陶瓷 - 聚合物复合材料的强度（提高1.37倍）和韧性（提高2.08倍）有显著增强（P < 0.05），突出了我们结构设计的有效性。此外，梯度设计进一步提高了复合材料的机械强度。值得注意的是，梯度复合冠的弯曲强度为138.3（±16.7）兆帕，韧性为9.0（±0.5）兆焦/立方米，抗压强度为113.7（±2.6）兆帕，这些值与天然牙釉质和牙本质相当，并显示出良好的生物安全性。
通过一系列研究精确制备了仿生梯度氧化锆/牙科树脂材料，有望进一步提高临床治疗效果。同时，该策略性设计也为其他牙科材料的性能改进提供了新思路。
精确制备了力学性能与天然牙齿匹配的梯度氧化锆/树脂复合材料，有望显著改善临床治疗效果。此外，该策略性设计为提高其他牙科材料的性能提供了新见解。
