The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
The Second Hospital of Jilin University, Changchun, 130012, China.
Sci Rep. 2024 Oct 29;14(1):25981. doi: 10.1038/s41598-024-76374-1.
Chronic Obstructive Pulmonary Disease (COPD) significantly impacts patients' quality of life and burdens healthcare systems. Magnesium is crucial for lung function and reducing respiratory disease risk. This study investigates the association between Magnesium Depletion Score (MDS) and COPD and explores whether inflammatory markers mediate this relationship. A cross-sectional analysis was conducted using data from 30,490 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. MDS was calculated based on diuretic use, proton pump inhibitors, renal function, and alcohol consumption. Univariable and multivariable logistic regression analyses were performed to assess the association between MDS and COPD, adjusting for potential confounders. Mediation analysis was used to examine the roles of neutrophils, serum albumin, and the Systemic Immune-Inflammation Index (SII). In the univariable logistic model, higher MDS was significantly associated with increased COPD risk. Specifically, compared to MDS = 0, the odds ratios (OR) for COPD were 2.50, 4.12, 6.13, 8.53, and 7.81 for MDS = 1, 2, 3, 4, and 5, respectively (all P < 0.001). In the multivariable model, the ORs were 1.79, 2.25, 2.71, and 3.44 for MDS = 1, 2, 3, and 4, respectively (all P < 0.001). Higher neutrophil levels and SII were positively associated with increased COPD risk, while higher serum albumin levels were inversely associated. Mediation analysis indicated that neutrophils, serum albumin, and SII significantly mediated the MDS-COPD relationship. Higher MDS is significantly associated with increased COPD risk, mediated by systemic inflammation markers. Improving magnesium levels could potentially reduce COPD risk, warranting further research on magnesium supplementation in COPD prevention and management.
慢性阻塞性肺疾病（COPD）显著影响患者的生活质量，并给医疗保健系统带来负担。镁对肺功能和降低呼吸疾病风险至关重要。本研究调查了镁耗竭评分（MDS）与 COPD 之间的关联，并探讨了炎症标志物是否介导这种关系。使用 2005 年至 2018 年国家健康和营养检查调查（NHANES）中 30490 名参与者的数据进行了横断面分析。根据利尿剂使用、质子泵抑制剂、肾功能和酒精摄入量计算 MDS。进行单变量和多变量逻辑回归分析，以评估 MDS 与 COPD 之间的关联，并调整潜在混杂因素。使用中介分析来检验中性粒细胞、血清白蛋白和全身免疫炎症指数（SII）的作用。在单变量逻辑模型中，较高的 MDS 与 COPD 风险增加显著相关。具体来说，与 MDS=0 相比，MDS=1、2、3、4 和 5 时 COPD 的比值比（OR）分别为 2.50、4.12、6.13、8.53 和 7.81（均 P<0.001）。在多变量模型中，MDS=1、2、3 和 4 时 COPD 的 OR 分别为 1.79、2.25、2.71 和 3.44（均 P<0.001）。较高的中性粒细胞水平和 SII 与 COPD 风险增加呈正相关，而较高的血清白蛋白水平与 COPD 风险降低呈负相关。中介分析表明，中性粒细胞、血清白蛋白和 SII 显著介导了 MDS-COPD 关系。较高的 MDS 与 COPD 风险增加显著相关，这与系统炎症标志物有关。提高镁水平可能会降低 COPD 风险，因此需要进一步研究镁补充剂在 COPD 预防和管理中的作用。
