Cappelli Federica, Mengozzi Alessandro
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
EMBO Mol Med. 2024 Nov;16(11):2655-2656. doi: 10.1038/s44321-024-00158-3. Epub 2024 Oct 29.
Environmental pollution is a major health problem that affects the health of individuals worldwide and is cumulative with other environmental stressors, contributing to the increasing prevalence of cancer, cardiometabolic, neurological and autoimmune diseases (Favé et al, 2018). Although being extensively studied, therapeutic strategies still rely primarily on exposure prevention, often with no option available to allow pollutant detoxification. In this issue of , Wang et al (Wang et al, 2024) investigated potential pharmacological strategies to allow the direct removal of phthalates, major environmental pollutants, from the liver.
环境污染是一个重大的健康问题，影响着全球个人的健康，并且与其他环境压力源相互累积，导致癌症、心脏代谢疾病、神经疾病和自身免疫性疾病的患病率不断上升（法韦等人，2018年）。尽管已进行了广泛研究，但治疗策略仍主要依赖于预防接触，通常没有可供选择的方法来实现污染物解毒。在本期杂志中，王等人（王等人，2024年）研究了从肝脏中直接去除主要环境污染物邻苯二甲酸盐的潜在药理学策略。
