Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Cell Mol Biol Lett. 2024 Oct 29;29(1):134. doi: 10.1186/s11658-024-00653-y.
Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the health care system. However, the current treatments for chronic pain are usually insufficient and cause many unwanted side effects. Chemokine C-X-C motif ligand 13 (CXCL13), formerly recognized as a B cell chemokine, binds with the cognate receptor CXCR5, a G-protein-coupled receptor (GPCR), to participate in immune cell recruitments and immune modulations. Recent studies further demonstrated that CXCL13-CXCR5 signaling is implicated in chronic pain via promoting neuroimmune interaction and neuroinflammation in the sensory system. In addition, some latest work also pointed out the involvement of CXCL13-CXCR5 in the pathogenesis of certain neurological diseases, including ischemic stroke and amyotrophic lateral sclerosis. Therefore, we aim to outline the recent findings in regard to the involvement of CXCL13-CXCR5 signaling in chronic pain as well as certain neurological diseases, with the focus on how this chemokine signaling contributes to the pathogenesis of these neurological diseases via regulating neuroimmune interaction and neuroinflammation. Strategies that can specifically target CXCL13-CXCR5 signaling in distinct locations may provide new therapeutic options for these neurological diseases.
慢性疼痛严重影响患者的生活质量。它给患者和医疗保健系统都带来了沉重的负担。然而，目前治疗慢性疼痛的方法通常效果不佳，且会引起许多不良反应。趋化因子 C-X-C 基元配体 13（CXCL13），以前被认为是一种 B 细胞趋化因子，与同源受体 CXCR5 结合，后者是一种 G 蛋白偶联受体（GPCR），参与免疫细胞募集和免疫调节。最近的研究进一步表明，CXCL13-CXCR5 信号通过促进感觉系统中的神经免疫相互作用和神经炎症参与慢性疼痛的发生。此外，一些最新的研究还指出，CXCL13-CXCR5 参与了某些神经系统疾病的发病机制，包括缺血性中风和肌萎缩侧索硬化症。因此，我们旨在概述 CXCL13-CXCR5 信号在慢性疼痛以及某些神经系统疾病中的作用的最新发现，重点关注这种趋化因子信号如何通过调节神经免疫相互作用和神经炎症来促进这些神经系统疾病的发病机制。能够在特定位置特异性靶向 CXCL13-CXCR5 信号的策略可能为这些神经系统疾病提供新的治疗选择。
